Organ-selective actions of steroid hormones
Author(s)
Bibliographic Information
Organ-selective actions of steroid hormones
(Ernst Schering Research Foundation workshop / edited by Günter Stock, Ursula-F. Habenicht, 16)
Springer-Verlag, c1995
- New York
- Berlin
Available at 1 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
  Thailand
  United Kingdom
  Germany
  Switzerland
  France
  Belgium
  Netherlands
  Sweden
  Norway
  United States of America
Note
Includes bibliographical references and index
Description and Table of Contents
Description
Steroids regulate differentiation, growth and functioning of many tissues via a nuclear receptor gene activation mechanism. Molecular biology has opened the way for more detailed investigation of the complex set of intracellular interactions contributing to organ-selective actions of steroids and steroid-like compounds such as vitamin D. In this volume leading experts address basic molecular mechanisms of tissue specificity and related issue, with the goal of attaining a better understanding of the underlying mechanisms of organ selective actions of steroids. Discussed is the extent to which tissue specificity might selectively be modified by chemical modification of the hormones and how this may be applied towards improved therapies by taking advantage of tissue selectivity.
Table of Contents
1 Development of Tissue-Selective Estrogen Receptor Modulators.- 2 Estrogen-Receptor and Antiestrogen-Receptor Complexes: Cell- and Promoter-Specific Effects and Interactions with Second Messenger Signaling Pathways.- 3 Analysis of Genetically Altered Mice Without Glucocorticoid Receptor.- 4 Organ-Selective Actions of Tamoxifen and Other Partial Antiestrogens.- 5 Progestin Regulation of Cell Proliferation in the Breast and Endometrium.- 6 Central Versus Endometrial Effects of Antiprogestins: Is Endometrial Selectivity Possible?.- 7 Androgen Action on the Bone.- 8 General Principles of Vitamin D Action and Mechanism-Based Search for Analogs with Specific Actions.- 9 Organ-Specific Actions of Vitamin D Analogs: Relevance of Rapid Effects.- Previous Volumes Published in this Series.
by "Nielsen BookData"