Perspectives in bioconjugate chemistry
著者
書誌事項
Perspectives in bioconjugate chemistry
American Chemical Society, 1993
- alk. paper
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注記
Contains a collection of articles previously published in the journal: Bioconjugate chemistry
Includes bibliographical references and indexes
内容説明・目次
内容説明
Includes all the reviews and teaching editorials published from 1989 and January 1993 in "Bioconjugate Chemistry". It includes sections on proteins, nucleic acids, synthetic polymers, targeted antibodies, and antibody-enzyme conjugates.
目次
- Introduction to bioconjugate chemistry. Part 1 Proteins: chemical modifications of proteins - history and applications
- radiohalogenation of proteins - a overview of radionuclides, labeling methods and reagents for conjugate labeling
- a brief survey of methods for preparing protein conjugates with dyes, haptens and cross-linking reagents. Part 2 Nucleic acids: a brief guide to nucleic acid chemistry
- conjugates of oligonucleotides and modified oligonucleotides - a review of their synthesis and properties
- sequence-selective DNA recognition by synthetic ligands
- DNA recognition by intercalator-minor-groove binder hybrid molecules. Part 3 Synthetic polymers: conjugates of anticancer agents and polymers - advantages of macromolecular therapeutics in vivo. Part 4 Targeted antibodies: recent advances with monoclonal antibody drug targeting for the treatment of human cancer
- the linkage of cytoxic drugs to monolonal antibodies for the treatment of cancer
- radiolabeling of monoclonal antibodies and fragments with technetium and rhenium. Part 5 Antibody-enzyme conjugates: enhancements of the thrombolytic potency of plasminogen activators by conjugation with clot-specific monoclonal antibodies
- conjugation of plasminogen activators and fibrin-specific antibodies to improve thrombolytic therapeutic agents
- purifying antibody-plasminogen activator conjugates
- generation of cytotoxic agents by targeted enzymes.
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