Biochemistry and physiology of thiamin diphosphate enzymes : proceedings of the International Meeting on the Function of Thiamin Diphosphate Enzymes, held in Blaubeuren, October 1990

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Biochemistry and physiology of thiamin diphosphate enzymes : proceedings of the International Meeting on the Function of Thiamin Diphosphate Enzymes, held in Blaubeuren, October 1990

edited by Hans Bisswanger and Johannes Ullrich

VCH, c1991

  • : gw
  • : us

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Includes bibliographical references and index

内容説明・目次

内容説明

More than half a century after the first isolation of thiamin, the scientific interest in this compound still persists, reflecting its key role in cell metabolism and in the nervous system. These proceedings survey the present understanding of the physiological functions of thiamin diphosphate and the various enzymes that depend on it (eg decarboxylases, -oxoacid dehydrogenases and transketolases). Stereochemical and kinetic aspects of their catalytic mechanisms, interaction and regulation, and cloning of their genes are also discussed. In addition, the importance of ThDP-dependent enzymes in brain metabolism and in pathological dysfunctions in the nervous system is described. Special feature: the recently discovered contribution of the pyruvate dehydrogenase complex to certain autoimmune diseases is considered, adding yet another dimension to the physiological role of this long-known vitamin.

目次

  • Thiamin diphosphate-dependent catalysis
  • pyruvate decarboxylase and related enzymes
  • a- oxoacid dehydrogenase complexes
  • pyruvate oxidase
  • transketolase
  • physiological and pathological aspects.

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