Regulation of the RAS signaling network
著者
書誌事項
Regulation of the RAS signaling network
（Molecular biology intelligence unit）
R.G. Landes Co. , Springer, c1996
- :International ISBN
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注記
Includes bibliographical references and index
内容説明・目次
- 巻冊次
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ISBN 9780412118616
目次
1. Genetics of RAS Signaling in Drosophila.- I. Introduction.- II. Background to the Experimental Systems.- III. Protein Tyrosine Kinase Receptors.- IV. Linking RAS with Tyrosine Kinase Receptors.- V. A Kinase Cascade Downstream of RAS.- VI. Nuclear Events.- VII. Concluding Remarks.- 2. RAS-Mediated Signal Transduction in C. elegans.- I. Introduction.- II. Genetic Approaches Used to Study Vulval Signal Transduction.- III. Genetic and Molecular Analysis of the let-60 RAS Gene.- IV. Genes Acting Upstream of RAS.- V. Genes Acting Downstream of RAS.- VI. Multiple Functions of the let-60 RAS-mediated Signal Transduction Pathway During C elegans Development.- 3. Mammals I: Regulation of RAS Activation.- I. Introduction.- II. Growth Factor/Cytokine Signaling.- III. Growth Factor Cascades: Autocrine Stimulation.- 4. Prenylation of RAS and Inhibitors of Prenyltransferases.- I. Introduction.- II. C-Terminal Modification of RAS Proteins.- III. Farnesyltransferase and Geranylgeranyltransferases.- IV. Mutational Analyses of Prenyltransferases.- V. Inhibitors of Prenylation.- VI. Biological Effects of Prenyltransferase Inhibitors.- 5. Mammals II: Downstream of RAS and Actin-Cytoskeleton.- I. RAS GAPs.- II. Oncogenic Mutations of RAS.- III. Effectors of RAS.- IV. Actin-Cytoskeleton.- V. G Proteins in the Rho Family (Rho, Rac and CDC42).- VI. RAS-Activated or -Repressed Genes.- 6. From RAS to MAPK: Cell-Free Assay System for RAS- and Rap 1-Dependent B-Raf Activation.- I. Introduction.- II. Cell-free Assay System for the RAS-dependent Activation of the MAP Kinase Cascade in Xenopus Oocyte Cytosol.- III. REKS.- IV. Raf Activation.- V. Conclusion.
- 巻冊次
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:International ISBN ISBN 9783540619796
内容説明
Aimed at students in molecular biology, biochemistry or medicine, and senior scientists conducting cancer research, this text provides readers with an overview of the major oncogene Ras. Standing orders placed before December 31st, 1996 will receive a 10% reduciton off the list price of all volumes published within the series between the order date and December 31st, 1997. This offer is valid as of June 1996, on a firm order basis only.
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