Human parvovirus B19
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書誌事項
Human parvovirus B19
（Monographs in virology, vol. 20）
Karger, 1997
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注記
Includes bibliographical references and indexes
内容説明・目次
内容説明
Parvovirus B19 is the only parvovirus that has been clearly linked to human disease. Since its discovery just over 20 years ago, our understanding of B19 at the molecular, cellular, epidemiological and clinical levels has developed rapidly: Today the link between B19 and erythema infectiosum, hydrops fetalis, chronic anemia and transient aplastic crisis is well established. This book provides the reader with comprehensive and detailed reviews of subjects important to understanding parvovirus B19, including - the structure and biochemistry of the virus - the clinical and epidemiological features of infection - the diagnosis of infection - the pathophysiology of disease - the host's immune response - treatment and prevention of disease Its expert contributions make this publication an essential and timely resource for clinicians, epidemiologists and public health policymakers in their endeavor to optimize treatment and prevention. It will also be appreciated by laboratory researchers interested in the physical and biological properties of the virus and the pathogenesis of B19 disease.
目次
- Part 1 The structure of human Parvovirus B19, M. Agbandje-McKenna, M.G. Rossmann: the tertiary structure of spherical viruses
- structure-function relationships for canine parvovirus and feline panleukopenia virus
- the structure of B19
- receptor interactions
- antigenicity. Part 2B 19 Parvovirus - biochemical and molecular features, C.R. Astell et al: the genome of B19 Parvovirus
- biological systems to study molecular aspects of B19 - the problems and the solutions
- replication of the B19 genome
- RNA transcripts
- transcripts encoding the NS and VP proteins
- small abundant RNA transcripts with coding potential
- NS-l proteins - characterization and probable functions
- characterization of the VP proteins
- proteins expressed by a small abundant RNAs - the ll- and 7.5-kDa proteins
- regulation of transcription - identification of promoter elements, regulation of RNA processing
- translational control. Part 3 Human Parvovirus B19 epidemiology and clinical manifestations, K.E. Brown: epidemiology - prevalence of B19 infection, incidence of B19 infection, epidemic behaviour and contagiousness, mechanism and routes of transmission
- clinical manifestations of B19 infection - asymptomatic infection, erythema infectiosum, B19 and arthritis, transient aplastic crisis, thrombocytopenia and neutropenia, hemaphagocytic syndrome, B19 infection during pregnancy, congenital infection and bone marrow failure, chronic bone marrow failure. Part 4 Unusual clinical manifestations reported in patients with Parvovirus B19 infection, T.J. Torok: cardiac disease
- cutaneous manifestations
- endocrine disorders
- haematologic disorders - aplastic anaemia, autoimmune haemolytic anaemia, chronic neutropenia, chronic pure red cell aplasia, hemophagocytic syndrome, hypersplenism, idiopathic thrombocytopenia purpura, lymphadenopathy and lymphadenitis, transient erythroblastopenia of childhood
- hepatobiliary tract disease
- neurologic disorders
- ocular disease
- renal disease
- lower respiratory tract disease rheumatic diseases - autoimmunity and immune-mediated inflammation, chronic fatigue syndrome, fibromyalgia, juvenile rheumatoid arthritis, spondyloarthropathy, systemic lupus erythematosus, vasculitis. Part 5 Human Parvovirus B19 - laboratory diagnosis, D.D. Erdman: specimen collection and preparation - serum, tissue
- antibody detection - immunoblot assays. enzyme immunoassays
- B19 virus and antigen detection - histological features, antigen detection
- B19 detection - dot-blot hybridization. (Part contents).
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