Therapeutic potential of melatonin : 2nd Locarno Meeting on Neuroendocrinoimmunology, Locarno, May 5-8, 1996
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Bibliographic Information
Therapeutic potential of melatonin : 2nd Locarno Meeting on Neuroendocrinoimmunology, Locarno, May 5-8, 1996
（Frontiers of hormone research, vol. 23）
Karger, c1997
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Includes bibliographical references and index
Description and Table of Contents
Description
Over the past decade, the potential of the pineal hormone melatonin as a therapeutic agent in a variety of diseases has been recognized. This book is the first to review the effect of melatonin in sleep disorders, its possible use as an immunoregulatory agent and clinical results obtained in cancer immunotherapy. Several papers are devoted to the pharmacological and molecular characterization of melatonin receptors in a variety of cell types. Other contributions further investigate the immunoenhancing effect of melatonin, such as in viral encephalitis and bacterial infections, and consider possible therapeutic indications. Melatonin is also reported to exert important hematopoietic effects by stimulating the production of novel T helper cell opioid cytokines. Other basic studies introduce new perspectives describing melatonin as a potent free radical scavenger. This book should be read by clinicians working in the fields of sleep disorders, oncology and infectious diseases as well as by scientists active in the field of neuroimmunomodulation. It will also be very useful to all those interested in melatonin as a therapeutic agent.
Table of Contents
- The pars tuberalis - a pituitary target for melatonin, D.G. Hazlerigg and P.J. Morgan
- the nocturnal melatonin peak and the photoperiodic response, P. Pevet and B. Pitrosky
- nuclear signalling of melatonin, C. Carlberg et al
- expression of membrane melatonin receptor mRNA in rat thymus and spleen, D. Pozo et al
- mechanisms of action of melatonin on the human immune system, membrane versus nuclear receptors, J.M. Guerrero et al
- melatonin rhythm in mice and its role in autoimmune diseases, A. Conti and G.J.M. Maestroni
- new T helper cell opioid cytokines as mediators of the immunological and haematopoietic action of melatonin, G.J.M. Maestroni et al
- the protective effect of melatonin in viral and bacterial infections, D. Ben-Nathan et al
- cellular and molecular actions of melatonin as an antioxidant, R.J. Reiter et al
- melatonin reduces the expression of excitotoxicity-triggered markers of apoptosis, H. Manev et al
- relationship between the pineal gland and experimentally induced malignant tumors, M. Karasek
- melatonin suppression of tumor growth in vivo - a novel mechanism involving inhibition of fatty acid uptake and metabolism, D.E. Blask et al
- modulation of melatonin secretion in cancer patients - possible mechanisms and significance for prognosis, diagnosis and treatment, C. Bartsch and H. Bartsch
- association of melatonin with nuclear grade and eostrogen receptor status in human breast cancer, G.J.M. Maestroni and A. Conti
- melatonin as a modulator of cancer endocrine therapy, P. Lissoni et al
- presurgical neuroimmunotherapy with melatonin and interleukin-2 in cancer patients, F. Brivio et al
- melatonin - shutting off the wakefulness system, P. Lavie et al
- potential therapeutic effects of melatonin, D. Gupta.
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