Molecular mechanisms of signalling and membrane transport
著者
書誌事項
Molecular mechanisms of signalling and membrane transport
（NATO ASI series, Series H,
Springer, c1997
大学図書館所蔵 全7件
注記
"Published in cooperation with NATO Scientific Affairs Division."
"Proceedings of the NATO Study Institute on Molecular Mechanisms of Signalling and Targeting, held on the Island of Spetsai, Greece, August 18-30, 1996."
Includes bibliographical references and index
内容説明・目次
内容説明
This volume provides a compilation of the main principles of signal transduction mechanisms. The reader will become familiar with the most recent developments on:- the structure and function of heterotrimeric G-proteins and their receptors;- the small GTPases Ras, Rho, Rab and Arf;- EGF receptor, Ca2+ and protein kinase C;- phosphoinositide kinases (PI-3 kinases);- phospholipases C and D;- ceramides and possible modulators of apoptosis;- transcription factors and gene activation;- multidrug resistance transporters.
目次
Heterotrimeric and Small G-Proteins.- Heterotrimeric guanine nucleotide binding proteins: structure and function.- G-Protein coupled receptors: structure, functions and mutations.- Heterologous expression of G protein-coupled receptors in yeasts: an approach to facilitate drug discovery.- The role of small GTPases in signal transduction.- Small GTPases in the morphogenesis of yeast and plant cells.- A role for G-protein ??-subunits in the secretory mechanism of rat peritoneal mast cells.- Subcellular localisation of ARF 1-regulated phospholipase D in HL60 cells.- Intra-and Intercellular Communication.- Electrophysiological aspects of growth factor signaling in NRK fibroblasts: the role of intercellular communication, membrane potential and calcium.- Cross-talk between calmodulin and protein kinase C.- Endocytosis and Vesicle Flow.- A function for Eps15 in EGF-receptor endocytosis?.- Proteins, sorted. The secretory pathway from the endoplasmic reticulum to the Golgi, and beyond.- Lipids and Intracellular Signalling.- The roles of PI3Ks in cellular regulation.- Phosphatidylinositol transfer protein, phosphoinositides and cell function.- Receptor regulation of phospholipases C and D.- Ceramide: a central regulator of the cellular response to injury and stress.- Ceramide changes during FAS (CD95/APO-1) mediated programmed cell death are blocked with the ICE protease inhibitor zVAD.FMK. Evidence against an upstream role for ceramide in apoptosis.- The structure, biosynthesis and function of GPI membrane anchors.- Enzyme assisted synthetic approaches to the inositol phospholipid pathway.- Regulation of Nuclear Transcription.- Coupling signal transduction to transcription: the nuclear response to cAMP.- Vitamin E and the metabolic antioxidant network.- Membrane Transport Proteins.- The molecular basis for pleiotropic drug resistance in the yeast Saccharomyces cerevisiae: regulation of expression, intracellular trafficking and proteolytic turnover of ATP binding cassette (ABC) multidrug resistance transporters.- Regulation of carbon metabolism in bacteria.
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