Developments in the commercial manufacture and applications of optically active compounds
著者
書誌事項
Developments in the commercial manufacture and applications of optically active compounds
（Chirality in industry, 2）
J. Wiley, c1997
- : pbk
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注記
Includes bibliographical references and index
内容説明・目次
- 巻冊次
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ISBN 9780471966807
内容説明
The manufacture and applications of chiral compounds continue to develop. Building on the "case studies" format of the first volume, this text concentrates on different syntheses and the developments in the field. It presents a comprehensive picture of the technologies required for the production of optically active molecules on the multi-Kg to high tonnage scales, as well as illustrating the breadth of application of the products of these technologies. This volume is divided into sections on physical methods and classical resolutions, biological methods and the chiral pool, and asymmetric synthesis. These are preceded by a chapter dealing with regulatory issues for chiral drugs and two chapters on chiral drug development which illustrates how widely the industrial practitioner must cast the net in pursuit of practical production methods. The book should be of interest to applied chemists and organic synthetic chemists.
目次
- Partial table of contents:
- Chiral Drugs: Regulatory Aspects (J. Blumenstein)
- Synthesis of Enantiomerically Pure Nucleosides (B. Bray, et al.)
- PHYSICAL METHODS AND CLASSICAL RESOLUTION
- Crystal Science Techniques in the Manufacture of Chiral Compounds (W. Wood)
- BIOLOGICAL METHODS AND CHIRAL POOL SYNTHESES
- Development of a Multi-Stage Chemical and Biological Process for an Optically Active Intermediate for an Anti-Glaucoma Drug (A. Blacker & R. Holt)
- ASYMMETRIC SYNTHESES BY CHEMICAL METHODS
- Asymmetric Hydrocyanation of Vinylarenes (A. Casalnuovo & T. Rajanbabu)
- Sharpless Asymmetric Epoxidation: Scale-up and Industrial Production (W. Shum & M. Cannarsa)
- Index.
- 巻冊次
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: pbk ISBN 9780471982845
内容説明
This second volume of Chirality in Industry contains new case histories from a wide range of contributors from industry or with strong industrial connections. While it is intended that the new volume will stand on its own, Volumes I and II taken together present an up-to-date and comprehensive picture of the technologies required to produce optically active compounds on a multi-kilogramme to high tonnage scale as well as illustrating the breadth of application of these technologies; the pharmaceuticals, agrochemicals, electronics, food, flavour and fragrance industries are all represented.
Chirality in Industry II
All new case histories
Unique industrial perspective on chiral technology
Emphasis on scale-up and process development
Comparison of biocatalysis, asymmetric synthesis and classical resolution approaches
The chiral infrastructure is now largely in place and there is no reason why large-scale production should not be possible for even moderately priced single enantiomer products. The successful industrial application of chiral chemistry depends on the integration of a range of supporting technologies and there are many examples in this volume of how widely the industrial practitioner must cast the net to achieve practical production methods. As with Volume I, this new volume is of particular interest to those professionally involved in the scale-up processes for single enantiomers. However, students and researchers involved in a more academic pursuit of optical activity will also benefit from some of the facets of large-scale thinking. An economic solution is still most likely to be a simple, elegant solution.
目次
Partial table of contents:
Chiral Drugs: Regulatory Aspects (J. Blumenstein).
Synthesis of Enantiomerically Pure Nucleosides (B. Bray, etal.).
PHYSICAL METHODS AND CLASSICAL RESOLUTION.
Crystal Science Techniques in the Manufacture of Chiral Compounds(W. Wood).
BIOLOGICAL METHODS AND CHIRAL POOL SYNTHESES.
Development of a Multi-Stage Chemical and Biological Process for anOptically Active Intermediate for an Anti-Glaucoma Drug (A. Blacker& R. Holt).
ASYMMETRIC SYNTHESES BY CHEMICAL METHODS.
Asymmetric Hydrocyanation of Vinylarenes (A. Casalnuovo & T.Rajanbabu).
Sharpless Asymmetric Epoxidation: Scale-up and IndustrialProduction (W. Shum & M. Cannarsa).
Index.
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