CiNii Books - Asthma

With increasing incidence, prevalence and mortality in many parts of the world, asthma continues to perplex the medical community. Despite an improved and expanded understanding of the epidemiology and pathobiology of this common clinical syndrome, and the many precise and targeted therapies, asthma remains a challenge. This exemplary reference -- with contributions by 213 leading experts from around the world -- examines the myths, the facts, the research, and the future of asthma and its management. An enlightening introduction provides a broad overview, history, definitions and clinical classifications. The remaining sections present every aspect of the illness and its treatment with detailed, focused clarity. Coverage includes: Epidemiology; Structure, Biology and Pathology; Inflammatory Cells; Inflammatory Mediators; Target Cells; Neural Mechanisms; Inducers and Triggers; Respiratory Physiology; Clinical Assessment; Therapy; and Management

Table of Contents

Foreword Roland H. Ingram, Jr. A. Introduction 1. Overview Editors 2. History of asthma Roger Ellul-Micalef 3. Definitions and clinical classification Ann J. Woolcock B. Epidemiology 4. Epidemiological trends Peter Burney 5. Asthma deaths Julian Crane, Neil Pearce, Carl Burgess, Richard Beasley 6. Ethnic differences C.M. Salome and Ann J. Woolcock 7. Risk factors: IgE and atopy Malcolm R. Sears 8. Indoor allergens as a risk factor for asthma Adnan Custovic and Martin Chapman 9. Risk factors: diet Scott T. Weiss 10. Risk factors: development and natural history Fernando D. Martinez 11. Genetics of atopy Carole L. Ober 12. Genetics of asthma Djerke Postma C. Structure, Biology and Pathology 13. Upper airways Hemalini Mehta and William W. Busse 14. Normal airway structure Manuel G. Cosio and Marina Saetta 15. Development of airways Charles G. Plopper, Reed Wu, Michelle M. Voit, Judith A. St. George 16. Postmortem pathology James C. Hogg and Richard C. Hegele 17. Bronchial biopsies Annika Laitinen, Lauri A. Laitinen, and Ismo Virtanen 18. Bronchoalveolar lavage studies Mark C. Liu 19. Inflammation: basic concepts Peter A. Ward 20. IgE Donata A. Vercelli 21. Animal models Debra J. turner and James G. Martin 22. Animal models for studying genetics of asthma Roman A. Pauwels, Guy F. Joos, and Johan C. Kips 23. Receptor mechanisms Peter J. Barnes and Michael M. Grunstein 24. Molecular and genetic basis of b-Adrenergic receptor function and regulation Stephen B. Liggett 25. Intracellular signalling mechanisms: the second messengers David A. Bass 26. Transcription factors Ian M. Adcock and Peter J. Barnes D. Inflammatory Cells 27. Mast cell involvement in asthma Yuji Shimizu and Lawrence B. Schwartz 28. Basophils John T. Schroeder and Lawrence M. Lichtenstein 29. Macrophages Galen B. Toews 30. Eosinophils Mary E. Strek and Alan R. Leff 31. Neutrophils Leonardo Fabbri, G. Caramori, M. Piattella and P. Mastrelli 32. T Lymphocytes in asthma pathogenesis C.J. Corrigan and A. Barry Kay 33. Dendritic cell population Patrick G. Holt 34. Platelets Clive P. Page 35. Interstitial and bronchial fibroblasts Patricia J. Sime, Guy Tremblay, Zhou Xing, Bengt Sarnstrand, Jack Gauldie 36. Epithelial cells as inflammatory cells Albert J. Polito and David Proud 37. The role of endothelial cells in asthma Philippe Gosset, Pascale Jeannin, Philippe Lassalle, MNichel Joseph and Andre-Bernard Tonnel 38. Cell adhesion molecules Joseph M. Pilewski and Steven M. Albelda E. Inflammatory Mediators 39. Histamine MaryBeth Hogan and Paul A. Greenberger 40. Leukotrienes Andrew R. Fisher and Jeffrey M. Drazen 41. Cyclooxygenase products Paul M. O'Byrne 42. Platelet-activating factors and its implications Paula L. Watson and James R. Snapper 43. Bradykinin Peter J. Barnes 44. Adenosine Diana L. Marquardt 45. Eosino

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Asthma

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