Current advances in ACE inhibition

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書誌事項

Current advances in ACE inhibition

edited by Graham A. MacGregor, Peter S. Sever

Churchill Livingstone, 1989

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注記

Proceedings of an International Symposium, Queen Elizabeth II Conference Centre, London UK

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内容説明・目次

内容説明

This volume stems from an international meeting on angiotensin converting enzyme inhibition which was held in London from 14th-17th February 1989. Leading researchers worldwide representing both basic and clinical science have contributed to an interdisciplinary approach to the subject of ACE inhibition. The 52 chapters contain contributions ranging from molecular biology to various clinical aspects of treatment with ACE inhibitors. Part one of the book provides current state-of-the-art papers recognised by experts in the field. The subject matter covers all aspects of ACE inhibition, and includes data relating to the potential use of ACE inhibitors, not only as conventional therapy in hypertension and heart failure, but also highlights areas of research relating to the recognition of renin-angiotensin systems in many organs and tissues outside the kidney, which clearly raises the possibilities of new targets for action of ACE inhibitors. The subject of vascular growth and the role of trophic factors including angiotensin is covered by several authors, and the concept of reversal by hypertrophy both vascular and myocardial with ACE inhibitors is considered. It also looks at aspects of ACE inhibition relating to protection of the kidney, diabetes, the ageing process, tumour growth, and lastly some insight into actions on the brain in relation to learning. The clinical use of ACE inhibitors is also well reviewed. Part two consists of papers based upon peer reviewed communications presented at the meeting and provides a bird's eye view of the breadth and depth of research currently being undertaken in this field.

目次

  • Part 1 State of the art: two putative active centres in human angiotensin I converting enzyme revealed by molecular cloning, F.Soubrier
  • angiotensin converting enzyme - localization, regulation and inhibition, C.I.Johnston and M.Kozuhki
  • pathophysiology and molecular biology of tissue renin, D.Ganten et al
  • angiotensin converting enzyme inhibition - renal effects and their role in reducing pressure, J.E.Hall
  • the role of endothelial-derived vasoactive substances in vascular smooth muscle growth and remodelling, M.Schachter
  • angiotensin II, cellular growth and the sequalae of hypertension, R.N.Re
  • vascular structure and blood pressure during and after treatment with ACE inhibitors and other drugs, M.J.Mulvany
  • local inhibition of vascular converting enzyme by converting enzyme inhibitors - functional and morphological aspects, T.Unger and P.Goheke
  • the long-term effects on blood pressure after ACE inhibitor treatment in young spontaneously hypertensive rats - clues to the pathogenesis of high blood pressure, S.B.Harrap and A.F.Lever
  • the vascular renin-angiotensin system in the response to converting enzyme inhibition, J.D.Swales and N.J.Samani
  • ACE inhibitors and prostaniods, B.M.Zusman
  • Nephron heterogeneity in essential hypertension - relevance to the action of ACE inhibitors, J.H.Laragh
  • angiotension converting enzyme inhibitors for diagnosis of renovascular hypertension, C.S.Wilcox
  • renal vascular actions of angiotensin converting enzyme inhibitors in essential hypertension, N.K.Hollenberg and G.H.Williams
  • clinical use of ACE inhibitors - combined therapy in hypertension, M.H.Weinberger
  • adverse effects of ACE inhibitors and the quality of life, A.Breckenridge
  • ACE inhibitors and progressive kidney damage, L.D.Dworkin
  • ACE inhibition and diabetes, M.A.D.H.Schalekamp
  • angiogensis - a role for the vascular renin-angiotensin system, G.M.Taylor et al
  • potential for ACE inhibitors to prolong life, B.Corman et al
  • ACE inhibition and cognition, J.M.Barnes et al
  • future use of ACE inhibitors, C.T.Dollery. Part 2 Recent advances: endogenous inhibitor of angiotensin converting enzyme identified from the rat heart, F.Ikemoto
  • inhibition of angiotensin converting enzyme by kinins, M.Sasaguri
  • captopril inhibits the influx of calcium into platelets, J.Gill et al
  • blood platelets - aggregation, manonyl dialdehyde concentration and SOD-1 activity in patients with coronary heart disease after captopril administration, W.Tkaczewski et al
  • components of the renin-angiotensin system in vitreous fluids from eyes with and without diabetic retinopathy, A.H.J.Danser. (Part Contents)

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