Nuclear matrix : structural and functional organization
著者
書誌事項
Nuclear matrix : structural and functional organization
Academic Press, c1995
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Research on the nuclear matrix has grown enormously since Bereney and Coffey first reported its isolation and initial characterization in 1974. Since then, more than 1000 papers have been published on the subject by numerous workers around the world. This is the first book devoted to reviewing the major developments in this growing field.
目次
The Nuclear Matrix: A Structural Mileu for Nuclear Genomic Function. The Architectural Organization of Nuclear Metabolism. The Structural Basis of Nuclear Function. Nuclear Domains and the Nuclear Matrix. The Nuclear Matrix and the Regulation of Chromatin Organization and Function. Contributions of Nuclear Architecture to Transcriptional Control. Chromatin Domains and Prediction of MAR Sequences. Scaffold/Matrix-Attached Regions: Structural Properties Creating Transcriptionally Active Loci. Origins of Replication and the Nuclear Matrix: The DHFR Domain as a Paradigm. The Nuclear Matrix and Virus Function. The Nuclear Matrix as a Site of Anticancer Drug Action. Nuclear Matrix Proteins as Structural and Function Components of the Mitotic Apparatus. Nuclear Matrix Isolated from Plant Cells. The Dynamic Properties and Possible Functions of Nuclear Lamins. Intracellular Structure and Nucleocytoplasmic Transport. Toward a Molecular Understanding of the Structure and Function of the Nuclear Pore Complex. Nuclear Pore Complex Proteins. Targeting and Association of Proteins with Functional Domains in the Nucleus: The Insoluble Solution. Nuclear Matrix Acceptor Binding Sites for Steroid Hormone Receptors: A Candidate Nuclear Matrix Acceptor Protein. Nuclear Matrix and the Cell Cycle. Specificity and Functional Significance of DNA Interaction with the Nuclear Matrix: New Approaches to Clarify the Old Questions. References. Subject Index.
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