Colony-stimulating factors : molecular and cellular biology

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書誌事項

Colony-stimulating factors : molecular and cellular biology

edited by John M. Garland, Peter J. Quesenberry, Douglas J. Hilton

Marcel Dekker, c1997

2nd ed

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注記

Includes index

内容説明・目次

内容説明

Concentrating on proven data and adopting a structure-function approach, this text provides grounding for an intricate understanding of the molecular biology, physiological mechanisms, and routine clinical use in disease settings of colony-stimulating factors (CSFs). This edition includes eight additional chapters, with updates of recently-discovered and established CSFs, each indexed individually.

目次

  • Overview: introduction to the haematopoietic system
  • surrogate assays for haematopoietic stem cell activity
  • receptors for haematopoietic regulators
  • regulation of the cell cycle by kinases and cyclins
  • gene organization and regulation
  • cytokines and apoptosis - the mechanism of regulation of cell death
  • haematopoietic microenvironments
  • extracellular matrix- and membrane-bound cytokines
  • transfection of stem cells and gene therapy. Colony-stimulating factor: granulocyte-macrophage colony-stimulating factor and its receptor
  • granulocyte colony-stimulating factor
  • human interleukin-3 - an overview
  • macrophage colony-stimulating factor
  • erythropoietic
  • the role of interleukin-4 in normal and malignant human haematopoietic effects of interleukin-1
  • kit-ligand-stem cell factor
  • interleukin-5. Cytokines: macrophages inflammatory protein-1 alpha
  • transforming growth factor-beta, tumour necrosis factor-alpha, and macrophage inflammatory protein-1 alpha are bidirectional regulators of haematopoietic cell growth
  • leukaemia inhibitory factor
  • interleukin-12 in haematopoiesis
  • ex vivo expansion of haematopoietic stem and progenitor cells
  • clinical use of cytokines.

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