Controlled drug delivery : challenges and strategies
著者
書誌事項
Controlled drug delivery : challenges and strategies
(ACS professional reference book)
American Chemical Society, c1997
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This volume discusses the challenges of creating controlled release dosage forms that will deliver new therapeutic agents based on high-molecular-weight molecules. It examines strategies for delivering drugs through resistant biological barriers and surveys a variety of topics, including drug targeting, self-regulated drug delivery, protein drug delivery, biosensors, cell and tissue engineering, new biomaterials, modeling methods, pharmacokinetics, and U.S. federal
regulations.
目次
- CONTROLLED DRUG DELIVERY: PAST, PRESENT, AND FUTURE
- INTRACELLULAR DELIVERY AND TARGETING
- 2. Intracellular Delivery of Peptides and Proteins
- 3. DNA Delivery Vectors for Somatic Cell Gene Therapy
- 4. Targetable Polymeric Drugs
- 5. Particle Engineering of Biodegradable Colloids for Site-Specific Drug Delivery
- 6. Site-Specific Drug Delivery in the Gastrointestinal Tract
- SELF-REGULATED DRUG DELIVERY
- 7. Feedback-Controlled Drug Delivery
- 8. Stimuli-Sensitive Drug Delivery
- 9. Sensocompatibility: Design Considerations for Biosensor-Based Drug Delivery Systems
- DELIVERY OF PEPTIDE AND PROTEIN DRUGS
- 10. Formulation of Proteins and Peptides
- 11. Stability of Peptides and Proteins
- 12. Peptide, Protein, and Vaccine Delivery from Implantable Polymeric Systems
- 13. Oral Immunization Using Microparticles
- 14. Peptide and Protein Delivery for Animal Health Applications
- TISSUE ENGINEERING AND GENE THERAPY
- 15. Protein Delivery by Microencapsulated Cells
- 16. Tissue Engineering: Integrating Cells and Materials To Create Functional Tissue Replacements
- 17. Drug Delivery Using Genetically Engineered Cell Implants
- 18. Ribozymes as Antiviral Agents
- NEW BIOMATERIALS FOR DRUG DELIVERY
- 19. Pseudo-Poly(amino acid)s: Examples for Synthetic Materials Derived from Natural Metabolites
- 20. Transductional Protein-Based Polymers as New Controlled-Release Vehicles
- 21. Synthetically Designed Protein Polymer Biomaterials
- 22. Biological Effects of Polymeric Drugs
- 23. New Biodegradable Polymers for Medical Applications: Elastomeric Poly(phosphoester-urethane)s
- 24. "Intelligent" Polymers
- MODELING OF CONTROLLED DRUG DELIVERY
- 25. Modeling of Self-Regulating Oscillatory Drug Delivery
- 26. Modeling Studies of Future Controlled-Release Devices
- 27. Computer Dynamics Simulation of Controlled Release
- REGULATORY ISSUES
- 28. Food and Drug Regulations for Controlled-Release Dosage Forms
- 29. Pharmacodynamic and Pharmacokinetic/ Considerations in Controlled Drug Delivery
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