Pharmacologic analysis of drug-receptor interaction
著者
書誌事項
Pharmacologic analysis of drug-receptor interaction
Lippincott-Raven, 1997
3rd ed
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
The thoroughly revised, updated Third Edition of this highly acclaimed text reflects the past four years' groundbreaking developments in receptor pharmacology, particularly the use of human recombinant receptor systems in drug design and development. Whereas prior editions focused on the correspondence of animal to human receptor systems, this new edition examines drug effects on human receptors obtained by recombinant technology, as well as on physiological natural receptor systems in animals. Two new chapters explain how to produce and use human recombinant receptor systems and discuss the interpretation of data from human recombinant receptor studies. Other chapters describe the use of receptor studies to measure and characterize the biological actions of drugs
目次
- Drug receptor/theory
- seven transmembrane receptor behaviour
- human recombinant receptor systems
- stimulus-response mechanisms
- drug response mechanisms
- diffusion and drug concentration in receptor compartments
- statistical assessment of biological significance from data
- affinity
- efficacy
- competitive antagonism
- allotopic, noncompetitive, and irreversible antagonism
- methods of drug and receptor classification
- kinetics of drug and reaction.
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