The design and analysis of sequential clinical trials
著者
書誌事項
The design and analysis of sequential clinical trials
（Statistics in practice）
J. Wiley, c1997
Rev. 2nd ed
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注記
Includes index
内容説明・目次
内容説明
This book details all aspects of sequential clinical trials from preliminary planning, through the monitoring of the trial, to the final analysis of the results. Emphasis is placed on the triangular test and other procedures based on straight line stopping boundaries. These methods allow for frequent or occasional interim analyses and permit the analysis of a wide variety of patient responses. Alternative procedures are also covered in detail, and these include -spending function methods, repeated confidence intervals and Bayesian approaches to sequential clinical trials.
目次
Clinical Trials.
Allocating Patients to Treatments.
Measurement of Treatment Difference.
The Design of a Sequential Trial Using the Boundaries Approach.
The Analysis of a Sequential Trial.
Alternative Approaches to the Design and Analysis of Sequential Clinical Trials.
Prognostic Factors.
The Comparison of More than Two Treatments.
Implementation of Sequential Methods: Some Examples.
References.
Appendix.
Index.
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