Eicosanoids and other bioactive lipids in cancer, inflammation, and radiation injury

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Eicosanoids and other bioactive lipids in cancer, inflammation, and radiation injury

edited by Kenneth V. Honn ... [et al.]

（Advances in experimental medicine and biology, v. 400A, 400B, 407, 469, 507）

Plenum Press, c1997-

  • 2, pt. A
  • 2, pt. B
  • 3
  • 4
  • 5

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注記

2: "Proceedings of the Third International Conference on Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, held October 13-16, 1993, in Washington, D.C." --T.p. verso. -- 3: "Proceedings of the Fourth International Conference on Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, held October 4-7, 1995, in Hong Kong" --T.p. verso. -- 4: "This volume constitutes the proceedings of the 5th International Conference on Eicosanoids and Other Bioactive Lipids in Cancer Inflammation and related diseases, which was held at the Sheraton Grand Torrey Pines in La Jolla, California, in September 1997" --Pref. -- 5: "This volume represents a collection of contributions from the 6th International Conference on Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Related Diseases held in Boston from September 12-15, 1999" --Pref

Includes bibliographical references and index

4- published by: New York : Kluwer Academic/Plenum Publishers

内容説明・目次

巻冊次

2, pt. B ISBN 9780306453601

内容説明

Over one hundred contributions detail advances in the molecular and cellular biology of eicosanoid production, as well as their role in signal transduction. One of the most exciting developments explored within this collection of articles is the expression of the novel isoform of cyclooxygenase (cox-2), which may play a large role in the development of anti-inflammatory drugs.

目次

  • A: Phospholipases: Regulation of Phosphoinsitide Phospholipases by G-Proteins
  • J. Exton. Biosynthetic Enzymes: (S)-Type Lipoxygenase and Cyclooxygenase Reaction Box Models Characterizing the Stereochemistry of the Dioxygenation Reaction W. Lehman. Receptors:Dual Effect of Propanonol on the Human Platelet Activation of Thrombin: Potentiation of Free Intracellular Ca2+ Mobilization and Inhibition of Phospholipase D Activity
  • S. Svetlov. Protein Kinases/Phosphatases: Diacylglycerol Second Messengers: Molecular Switches in Growth Control
  • R. Bell. Inhibitors of Bioactive Lipids and Signal Transduction: Carcinogenesis: Cell Growth I: Part B: Apoptosis and Differentiation: Radiation-Induced Apoptosis in Tumors: Effects of Radiation Modulating Agents
  • L. Milas. Cytokines and Bioactive Lipids in Inflammation: Effects of GM-CSF on Leukotriene B4 Synthesis in Human Neutrophils: Facilitation of the Priming Effect by Autologous Plasma
  • E. Krump. Cell Motility and Cytoskeletal Alterations: Apoptosis in Tumor Biology and Therapy
  • R. Meyn. Adhesion Mechanisms in Inflammation and Metastasis: Radioprotection and Radiosensitization: Dietary Modulation and Prevention: Clinical Studies. 121 additional Articles. Index
巻冊次

3 ISBN 9780306454875

内容説明

This volume constitutes, in part, the proceedings of the Hong Kong Conference on "Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury" held in Hong Kong in October 1995. It contains papers by the symposium speakers, as well as poster contributions from researchers in this field. Since the discovery of "PROSTAGLANDIN-LIKE' substances 60 years ago. much has been learned. EICOSANOID is the new term that is used to include prostaglandins. thromboxanes, leukotrienes, lipoxins, isoprostanes, depoxilins, hydroxy acids, epoxy and hydroperoxy fatty acids. The conference focussed on recent development in underatanding the role of EICOSANOIDS in inflammation, cancer, and radiation damage. At the confer- ence, we also highlighted advances in newly developing areas such as "NO," "A POP- TOSIS and "ANANDAMIDE." The discovery of the structures of genes that encode several key enzymes and receptors of the Eicosanoid cascade, has allowed us to include reports in the "Alteration of the Gene Expression" section that reflects the most recent de- velopments in regulation for PGH-synthase and lipoxygenases. The editors are convinced that this volume will be an up-to-date and useful reference for investigators in both basic and clinical research.

目次

  • Lipoxygenase: Studies on the Active Site of Leuktriene A4 Hydrolase
  • A. Wetterholm, et al. PGH Synthase: Disruption of the Mouse Cyclooxygenase I Gene: Characteristics of the Mutant and Areas of Future Study
  • R. Langenbach, et al. Alteration of Gene Expression: Characterization of Prostaglandin H Synthase-2 Deficient Mice and Implications for Mechanisms of NSAID Action
  • S.G. Morham, et al. Receptors: Structure and Regulation of Platelet Activating Factor Receptor Gene
  • T. Shimizu, H. Mutoh. Inflammation: PGE2 Regulation of B Lymphocytes and T Helper 1 and T Helper 2 Cells: Induction of Inflammatory Versus Allergic Response
  • E.R. Fedyk, et al. Signal Transduction: Plasma Membrane Guanylate Cyclase: A Multimodule Transduction System
  • R.K. Sharma, T. Duda. Anandamide: Anandamide Amidohydrolase from Porcine Brain: Partial Purification and Characterization
  • N. Ueda, et al. PAF: Cloning and Characterization of a Murine Platelet-Activating Factor Receptor Gene
  • S. Ishii, et al. Cell Growth and Apoptosis: Clinical Studies: Poster Sessions: 76 Additional Articles. Index.
巻冊次

4 ISBN 9780306461385

内容説明

Since their discovery over 60 years ago, eicosanoids have come to represent a diverse family of bioactive lipid modulators, including prostaglandins, thromboxanes, leukotrienes, lipoxins, isoprostanes, hepoxilins, hydroxy acids, epoxy and hydroxy fatty acids. This book contains conference presentations regarding the regulation of eicosanoid enzymes and, in particular, cyclooxygenases, lipoxygenases, and phospholipases. In addition, the latest evidence over the last seven years has led to the identification of a number of receptors for these bioactive lipids. The new field of isoprostanes is also represented. It has become increasingly evident that eicosanoids play a critical role in signal transduction, both in normal cells and in pathological processes. These aspects are discussed in relation to cellular events, such as apoptosis, angiogenesis, and cancer prevention and treatment.

目次

Regulation of Eicosanoid Enzymes. Cyclooxygenases. Phospholipases/PAF. Receptors. Leukotrienes and Lipoxins. Isoprostanes. Signal Transduction. Bioactive Lipids in Inflammation. Linoleic and Linolenic Acids. Anandamide and Other Bioactive Lipids. Apoptosis. Cancer Prevention and Treatment. Bioactive Lipids in Non-Mammalian Cells. Contributors. Index.
巻冊次

5 ISBN 9780306472831

内容説明

This volume represents a collection of contributions from the 6th International Conference on Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Related Diseases held in Boston from September 12-15, 1999. The mission of this meeting was to bring together senior and junior investigators to both announce and examine their recent advancements in cutting-edge research on the roles and actions of lipid mediators and their impact in human physiology and disease pathogenesis. The meeting focused on new concepts in these areas of interest to both clinicians and researchers. The program included several outstanding plenary lectures and presentations by leading experts in the fields of cancer and inflammation. In addition, the Boston meeting presented three Young Investigator awards, one in each of the major focus areas. The meeting was exciting and proved to be very memorable. The program was developed with an emphasis on recent advances in molecular and of lipid mediators relevant in cellular mechanisims involved in the formation and actions inflammation and cancer. Plenary lectures were presented by Prof. Bengt Sammuelsson (Karolinska Institute, Stockholm; 1982 Nobel Laureate in Physiology or Medicine) and Prof. E. 1. Corey (Harvard University; 1990 Nobel Laureate in Chemistry). Both of these plenary lectures were held on Day 1, which set an exciting tone for this meeting. Immediately following these plenary lectures, three simultaneous breakout sessions were held, one of inflammation, a second on cancer and synthesis of novel inhibitors, and a third on enzymes-lipoxygenases/cyclooxygenases and inhibitors.

目次

Phospholipases. Lipoxygenases and Cyclooxygenases. Leukotrienes and Lipoxins. Enzymes in Eicosanoid Biosynthesis and Metabolism. Receptors, Agonists and Antagonists. Cancer and Inhibitors of Eicosanoid Biosynthesis. Nitric Oxide, Cox-2 and Apostosis. Signaling Pathways. Hydroxy Fatty Acids, Lipids and Isoeicosanoids. Knock-out Animal Models. Contributors. Index.

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