Basic clinical radiobiology

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書誌事項

Basic clinical radiobiology

edited by G. Gordon Steel

Arnold , Oxford University Press, 1997

2nd ed

大学図書館所蔵 件 / 全5件

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

This is a basic teaching book for radiation oncologists, radiation physicists, and radiobiologists, setting out the biological basis of radiation therapy. Early chapters deal with essential areas of science, including cell proliferation in tumours and normal tissues, principles of radiation cell killing, theoretical and modelling approaches, and molecular aspects of radiobiology. Subsequent chapters deal with the applications of radiobiology to clinical radiotherapy. The principles of fractionalism are described in detail, leading to the rationale of current approaches to the improvement of radiotherapy schedules. Also discussed are efforts to beat hypoxia in tumours, brachytherapy, the principles and use of particle beams, the combination of radiotherapy and chemotherapy, hyperthermia, targeted radiotherapy, and current efforts to individualize treatment with radiation therapy. This second edition has been updated and expanded to include advances in molecular growth. Each chapter concludes with a list of key points, and there are frequent cross-references between chapters.

目次

  • Introduction - the significance of radiobiology for radiotherapy
  • the growth of tumours
  • cell proliferation in tumours
  • proliferative and cellular organization of normal tumours
  • radiation response and tolerance of normal tissues
  • clonogenic cells and the concept of cell survival
  • models of radiation cell killing
  • DNA damage and cell killing
  • genetic control for the cellular response to ionizing radiation
  • dose-response relationships in radiotherapy
  • clinical manifestations of normal-tissue damage
  • time-dose relationships in radiotherapy
  • the linear-quadratic approach to fractionation and calculation of isoeffect relationships
  • hyperfractionation and accelerated radiotherapy
  • the oxygen effect
  • overcoming hypoxic radioresistance
  • the radiobiology of tumours
  • the dose-rate effect - brachytherapy
  • particle beams in radiotherapy
  • combination of radiotherapy and chemotherapy - principles
  • combination of radiotherapy and chemotherapy - clinical application and evaluation
  • re-treatment tolerance of normal tissues
  • hyperthermia
  • targeted radiotherapy
  • individualization of radiotherapy.

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