Polypeptide and protein drugs : production, characterization and formulation
著者
書誌事項
Polypeptide and protein drugs : production, characterization and formulation
（Ellis Horwood series in pharmaceutical technology）
E. Horwood, 1991
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Polypeptide and protein drugs are becoming the focus of intense research but many problems are encountered with the synthesis, characterization, formulation and quality control of such drugs. This book provides workers in the field with a comprehensive review of recent developments in polypeptide and protein chemistry and biology relevant to their exploitation as pharmaceuticals. Topics covered include the structure and folding of proteins, polypeptide function, the current status of polypeptide pharmaceuticals, quality control and safety. There is comprehensive discussion of specific peptides including LHRH analogues, insulin, monoclonal antibodies, vaccines and blood glycoproteins.
目次
- Protein structure
- protein folding
- site specific proteins
- peptide synthesis
- recombinant technology
- current status of polypeptide pharmaceuticals
- preclinical efficacy and toxicity studies
- recombinant products
- approach to regulatory requirements
- problems with hgih molecular weight proteins and glycoproteins
- monoclonal antibodies
- vaccines
- blood products
- freezedrying of proteins
- routes for peptide delivery
- polypeptide formulation.
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