Lipophilicity in drug action and toxicology
Author(s)
Bibliographic Information
Lipophilicity in drug action and toxicology
（Methods and principles in medicinal chemistry / edited by R. Mannhold ... [et al.], v. 4）
VCH, c1996
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Note
Includes bibliographical references
Description and Table of Contents
Description
This work features coverage of lipophilicity in drug action and toxicology.
Table of Contents
- Lipophilicity: the empirical tool and the fundamental objective - an introduction, V. Pliska, B. Testa and H. Van de Waterbemmd
- lipophilicity: a history, M.S. Tute
- thermodynamics of van der Waals and hydrophobic interactions, R. Zahradnik and P. Hobza
- intramolecular interactions encoded in lipophilicity: their nature and significance, B. Testa, P.-A. Carrupt, P. Gaillard and R.-S. Tsai
- lipophilicity measurement by reversed-phase high-performance liquid chromatography (RP-HPLC), H. van de Waterbeemd, M. Kansy, B. Wagner and H. Fischer
- centrifugal partition chromatography for lipophilicity measurements, R.-S. Tsai, G. Lisa, P.-A. Carrupt and B. Testa
- assessment of distribution-pH profiles, A. Avdeef
- estimation of lipophilicity by reversed-phase thin-layer chromatography, R. Mannhold, K. Dross and C. Sonntag
- the future of log P calculation, A.J. Leo
- theoretical calculation of partition coefficients, W.G. Richards
- cellular automata model of partitioning between liquid phases, L.B. Kier and C.-K. Cheng
- the molecular lipophilicity potential (MLP): a new tool for log P calculations and docking, and in comparative molecular field analysis (CoMFA), P.-A. Carrupt, et al
- hydrophobic fields in quantitative structure-activity relationships, G. Folkers and A. Merz
- physico-chemical and biological factors that influence a drug's cellular permeability by passive diffusion, R.A. Conradi, et al
- the role of lipophilicity in biological response to drugs and endogenous ligands, V. Pliska
- membrane transport and cellular distribution, S. Balaz
- applications of a solvation equation to drug transport properties, M.H. Abraham and H.S. Chadra
- environmental hazard assessment using lipophilicity data, R.L. Lipnick
- lipophilicity in peptide chemistry and peptide drug design, J.-L. Fauchere
- side chain lipophilicity of noncoded alpha-amino acids: pi-values
- the application of the intermolecular force model to bioactivity, peptide and protein quantitative structure-activity relationships, M. Charton
- lipophilicity descriptors for structure-property correlation studies: overview of experimental and theoretical methods and a benchmark of log " calculations, H. van de Waterbeemd and R. Mannhold.
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