Vaccines, vaccination, and the immune response

著者

書誌事項

Vaccines, vaccination, and the immune response

Gordon Ada, Alistair Ramsay

Lippincott-Raven, c1997

大学図書館所蔵 件 / 全6件

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注記

Includes bibliographical references (p. 203-236) and index

内容説明・目次

内容説明

This volume reviews current work on new vaccines and defines the key immunological principles that govern vaccine development. The opening section describes current vaccines and those in late-stage clinical trials, surveys national and international immunization programmes and highlights future needs and opportunities in vaccine development. A major portion of the text examines the innate and adaptive immune systems, the roles of different immune responses in combatting infection, the mechanisms by which infectious agents invade or subvert immune responses and the most effective ways of enhancing or selectively inducing different immune responses. The authors also discuss vaccine design, including peptide-based vaccines, rDNA technology, genetic (DNA) preparations and methods for producing vaccine perparations in plants. The final section explores the prospects of immunotherapy for tumours, autoimmune diseases and fertility control.

目次

  • Part 1 Past achievements and future needs: historical
  • traditional-type vaccines and vaccination practices
  • national and international vaccine programmes
  • future vaccine needs and opportunities. Part 2 The mammalian immune system: the nature and contribution of innate immunity
  • the nature of the mammalian adapative immune system
  • the nature of the adaptive immune system - regional immunity
  • the immune system of the neonate. Part 3 The role of different immune processes and their evasion by infectious agents: the role of different immune responses in the prevention, control and clearance of infection
  • the evasion, suppression and/or counteraction of immune responses by micro-organisms
  • the immunological requirements for successful vaccination. Part 4 Optimizing systemic and regional immune reponses: the selective induction of different immune responses
  • mucosal immune responses
  • immunopotentation of immune responses. Part 5 Vaccination against self/self-like components: modulation of hormone action
  • immunization to control fertility
  • immunization to eradicate tumours
  • immunization to prevent/control autoimmune diseases. Part 6 General aspects of vaccine development, safety and use: factors affecting the feasibility of vaccine development
  • assessing vaccine safety
  • quality assurance of vaccines
  • immunological parameters of vaccine efficacy in pre- and post-registration stages - the advantages of simple diagnostic tests
  • vaccine programmes - infants, adolsecents, adults and the elderly
  • the social acceptibility of vaccination.

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