Toxicology of the hematopoietic system
著者
書誌事項
Toxicology of the hematopoietic system
（Comprehensive toxicology / editors-in-chief, I. Glenn Sipes, Charlene A. McQueen, A. Jay Gandolfi, v. 4）
Pergamon, 1997
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This volume reviews our current understanding of the hematopoietic system and toxic effects on its components. The work is arranged in six parts. The first provides a background on hematotoxicology, describes the components of blood and blood-forming organs and reviews the complex process of hematopoiesis. Sections two, three, and four describe toxic effects on erythrocytes, leukocytes and hemostasis, respectively, and include discussions on putative agents and mechanisms, as well as the diagnosis and treatment, of these disorders. Section five addresses human hematopoietic stem cells, which represent an important target tissue that is amenable to in vitro testing. The last section deals with risk assessment in both the clinical and preclinical setting.
目次
Section 1: Introduction.
Introduction to hematotoxicology (J.C. Bloom). Hematopoiesis: Structure-Function relationships in bone marrow and spleen (K.M. Young, L. Weiss).
Section 2: The Erythron.
Evaluation of red cells and erythropoiesis (W. Fried). Nonimmune hemolysis and toxic methemorglobinemia (M.B. Dabrow, T.G. Gabuzda). Drug-induced immune hemolytic anemia (A. Salama). Toxic effects on erythrogenesis (R.T. Means Jr). Comparative biology and toxicology of the erythron (J.E. Smith).
Section 3: The Leukon.
Evaluation of granulocytes and mononuclear phagocytes (J.L. Liesveld, M.A. Lichtman). Response of granulocytes to toxic injury (A.V. Pisciotta). Evaluation of lymphoid cells and response to toxic injury (J.B. Margolick, A.D. Donnenberg). Leukemogenesis as a toxic response (R.D. Irons). Comparative leukocyte biology and toxicology (V.E.O. Valli, J.P. McGrath).
Section 4: Hemostasis.
Overview of hemostatic mechanisms (J.B. Lawrence). Evaluation of platelets and thrombopoiesis (P. Badenhorst, H.F. Kotze). Modulation of platelet function by xenobiotics: toxicologic implications (J.A. Jakubowski). Response of thrombocytes to toxic injury (R.H. Aster). Modulation of coagulation and fibrinolytic systems by therapeutic and nontherapeutic agents (T.W. Love, W.F. Novotny).
Section 5: Risk Assessment.
Human hematopoietic stem cells: laboratory assessment and response to toxic injury (R.E. Parchment, M.J. Murphy Jr). Analysis and risk assessment of hematological data from clinical trials (A. Szarfman, L. Talarico, J.G. Levine). Preclinical risk assessment for hematotoxicity: animal models and in vitro systems (A. Deldar, R.E. Parchment). Evaluation and interpretation of hematologic data in preclinical toxicology (R.L. Hall).
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