The endocrinology of bone

著者

書誌事項

The endocrinology of bone

edited by S. Farrow

Society for Endocrinology, 1997

大学図書館所蔵 件 / 全2件

この図書・雑誌をさがす

注記

Proceedings of a symposium held at University College London Medical School

Reprinted from the Journal of Endocrinology, v.154, suppl., September 1997 -- T.p. verso

Includes bibliographical references

内容説明・目次

内容説明

Specialists examine the science and medicine of bone endocrinology in this book. The interest in the use of parathyroid hormone (PTH) as a therapy for osteoporosis, and the issue of the role of polymorphisms in the vitamin D receptor in the genetic element of osteoporosis is discussed. The nature and functions of PTH receptors are also debated, as are the functions and significance in the renal and skeletal systems of the newly-cloned PTH receptor. The clinical management of hypercalcaemic syndromes is also covered. A section of the book covers parathyroid hormone-related peptide (PTD-RP). PTH-RP was first described in humoral hypercalcaemia of malignancy, and also has a role in the normal development of the skeleton. The book asks the question: is it a hormone or a cytokine? The vitamin D axis is also analyzed and reviewed with regard to the molecular basis of its actions and its interactions with the retinoid receptors in normal and disease states, such as vitamin D-resistant rickets. The basis for inherited vitamin D pseudo-deficiency or Prader rickets in children is also described. The fundamentals of bone biology are examined with respect to the biology of osteoclasts and the role of integrins. The latter have potential as targets for therapies in bone disease, including osteporosis.

「Nielsen BookData」 より

詳細情報

ページトップへ