The endocrinology of bone
Author(s)
Bibliographic Information
The endocrinology of bone
Society for Endocrinology, 1997
Available at 2 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
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  United Kingdom
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Note
Proceedings of a symposium held at University College London Medical School
Reprinted from the Journal of Endocrinology, v.154, suppl., September 1997 -- T.p. verso
Includes bibliographical references
Description and Table of Contents
Description
Specialists examine the science and medicine of bone endocrinology in this book. The interest in the use of parathyroid hormone (PTH) as a therapy for osteoporosis, and the issue of the role of polymorphisms in the vitamin D receptor in the genetic element of osteoporosis is discussed. The nature and functions of PTH receptors are also debated, as are the functions and significance in the renal and skeletal systems of the newly-cloned PTH receptor. The clinical management of hypercalcaemic syndromes is also covered. A section of the book covers parathyroid hormone-related peptide (PTD-RP). PTH-RP was first described in humoral hypercalcaemia of malignancy, and also has a role in the normal development of the skeleton. The book asks the question: is it a hormone or a cytokine? The vitamin D axis is also analyzed and reviewed with regard to the molecular basis of its actions and its interactions with the retinoid receptors in normal and disease states, such as vitamin D-resistant rickets. The basis for inherited vitamin D pseudo-deficiency or Prader rickets in children is also described.
The fundamentals of bone biology are examined with respect to the biology of osteoclasts and the role of integrins. The latter have potential as targets for therapies in bone disease, including osteporosis.
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