Connections, cognition and Alzheimer's disease
著者
書誌事項
Connections, cognition and Alzheimer's disease
（Research and perspectives in Alzheimer's disease）
Springer-Verlag, c1997
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Alzheimer's disease invades the brain from the inside. Unlike an abcess, a metas- tasis or an infarct, the disease follows specific tracks and avoids certain cortical areas while flourishing in others. Any observer is struck by the exquisite selectiv- ity of the lesions and could, indeed, conclude that Alzheimer's disease knows neuroanatomy. However, should the term "disease" be used to define this disor- der? Several genes, located on at least three different chromosomes, have been implicated in the disease. The ApoE4 genotype has been shown to be an impor- tant risk factor, but dementia pugilistica also suggests that environment can be involved in at least some aspects of the disorder. These data favor the now preva- lent view that Alzheimer's disease should instead be considered as a syndrome, and probably all of the contributors to this volume are ready to endorse this point of view. If "Alzheimer's syndrome" is the final common pathway to several pathoge- netic mechanisms, there should be an event at one point in the course of the spe- cific etiology that triggers a somewhat stereotypic diffusion process along some neural connections.
Scientists who are fascinated by the way in which the ner- vous system has morphologically encoded its function after a long phylogenetic history are also fascinated by this pathological progression of Alzheimer's syn- drome.
目次
Aspects of Cortical Destruction in Alzheimer's Disease.- Cortical Feedforward and Cortical Feedback Neural System in Alzheimer's Disease.- Plaques and Tangles: Where and When?.- Cortical Mapping of Pathological Tau Proteins in Several Neurodegenerative Disorders.- Neurofibrillary Tangles are Associated with the Differential Loss of Message Expression for Synaptic Proteins in Alzheimer's Disease.- Morphologic and Neurochemical Characteristics of Corticocortical Projections: Emergence of Circuit-Specific Features and Relationships to Degenerative Changes in Alzheimer's Disease.- Reduced Neuronal Activity is one of the Major Hallmarks of Alzheimer's Disease.- Neurodegenerative Alzheimer - Like Pathology in PDAPP 717V ?F Transgenic Mice.- Molecular Mechanisms of Synaptic Disconnection in Alzheimer's Disease.- Is Alzheimer's Disease Accelerated Aging? Different Patterns of Age and Alzheimer's Disease Related Neuronal Losses in the Hippocampus.- Connections and Cognitive Impairment in Alzheimer's Disease.- Distributed Hierarchical Neural Systems for Visual Memory in Human Cortex.- Brain and Language.
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