Eukaryotic mRNA processing
著者
書誌事項
Eukaryotic mRNA processing
（Frontiers in molecular biology, 17）
New York : IRL Press at Oxford University Press, c1997
- : hbk
- : pbk
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注記
Includes bibliographical references and index
内容説明・目次
- 巻冊次
-
: pbk ISBN 9780199634170
内容説明
This volume focuses on the major aspects of post-transcriptional mRNA processing in the nucleus of eukaryotic cells. Each of the described mRNA reactions is required for proper gene expression and can also serve as a control point for regulating the expression of many genes, for example during embryonic development or in different cell types. The different chapters review the assembly of newly synthesized nuclear mRNA transcripts into hnRNP particles and
catalytically active spliceosomes; the structure and mechanism of action of small nuclear ribonucleoprotein particles and protein factors that catalyse pre-mRNA splicing in mammalian cells and in yeast; the regulation of gene expression and generation of protein isoform diversity by alternative splicing; the
mechanisms of 3' end cleavage and polyadenylation; the architecture of the cell nucleus in relation to these processes and to the localization of the relevant substrates and factors; the diverse mechanisms of RNA processing by ribozymes and their potential relevance for nuclear mRNA processing; the mechanism of spliced-leader addition by trans-splicing in nematodes and trypanosomes; and the process of insertion/deletion mRNA editing in kinetoplasmid protozoa. In each chapter, leading
researchers have provided detailed, critical reviews of the history, experimental approaches, major advances, current ideas and models, as well as future directions, for each of these active areas of research.
目次
- 1. RNA-catalysed RNA processing
- 2. Nuclear organization of pre-mRNA splicing factors and substrates
- 3. The packaging of pre-mRNA
- 4. Spliceosome assembly
- 5. snRNP structure and function
- 6. Mammalian pre-mRNA splicing factors
- 7. Pre-mRNA splicing factors in the yeast Saccharomyces cerevisiae
- 8. Alternative pre-mRNA splicing
- 9. Capping, methylation, and 3'-end formation of pre-mRNA
- 10. Trans-splicing
- 11. mRNA editing
- 巻冊次
-
: hbk ISBN 9780199634187
内容説明
This volume focuses on the major aspects of post-transcriptional mRNA processing in the nucleus of eukaryotic cells. Each of the described mRNA reactions is required for proper gene expression and can also serve as a control point for regulating the expression of many genes, for example during embryonic development or in different cell types. This book is intended for postgraduates, post-doctoral researchers, and academic staff in eukaryotic molecular biology.
目次
1: RNA-catalysed RNA processing. 2: Nuclear organization of pre-mRNA splicing factors and substrates. 3: The packaging of pre-mRNA. 4: Spliceosome assembly. 5: snRNP structure and function. 6: Mammalian pre-mRNA splicing factors. 7: Pre-mRNA splicing factors in the yeast Saccharomyces cerevisiae. 8: Alternative pre-mRNA splicing. 9: Capping, methylation, and 3'-end formation of pre-mRNA. 10: Trans-splicing. 11: mRNA editing
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