Matrix metalloproteinases

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Bibliographic Information

Matrix metalloproteinases

edited by William C. Parks and Robert P. Mecham

(Biology of extracellular matrix)

Academic Press, c1998

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Includes bibliographical references and index

Description and Table of Contents

Description

The chapters in this book thoroughly cover the structure, regulation, and function of matrix metalloproteinases, and provide information on the latest strategies to inhibit enzyme activity. This work will be an indispensable reference tool for investigators with an interest in extracellular matrix biology, matrix turnover, enzymology and biochemistry of proteinases, developmental biology, pathology, and therapeutic interventions.

Table of Contents

Contributors. Preface. The Matrix Metalloproteinase Family, J.F. Woessner, Jr.. Interstitial Collagenases, J.J. Jeffrey. Stromelysins 1 and 2, H. Nagase. 72-kDa Gelatinase (Gelatinase A): Structure, Activation, Regulation, and Substrate Specificity, A.E. Yu, A.N. Murphy and W.G. Stetler-Stevenson. Gelatinase B: Structure, Regulation, and Function, T.H. Vu and Z. Werb. Matrilysin, C.L. Wilson and L.M. Matrisian. Macrophage Elastase (MMP-12), S.D. Shapiro and R.M. Senior. Membrane-Type Matrix Metalloproteinases and Cell Surface-Associated Activation Cascades for Matrix Metalloproteinases, V. Knauper and G. Murphy. Substrate Specificity and Mechanism of Substrate Recognition of the Matrix Metalloproteinases, V. Imper and H.E. Van Wart. Synthetic Inhibitors of Matrix Metalloproteinases, P.D. Brown. Matrix Metalloproteinases in Tissue Repair, W.C. Parks, B.D. Sudbeck, G.R. Doyle and U.K. Saariahlo-Kere. Regulation of Matrix Metalloproteinase Gene Expression, M.E. Fini, J.R. Cook, R. Mohan and C.E. Brinckerhoff. Index.

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