Direct methods for solving macromolecular structures
著者
書誌事項
Direct methods for solving macromolecular structures
（NATO ASI series, Series C . Mathematical and physical sciences ; no. 507）
Kluwer Academic Publishers, c1998
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注記
"Proceedings of the NATO Advanced Study Institute on Direct Methods for Solving Macromolecular Structures, Erice, Italy, May 22-June 02, 1997."
"Published in cooperation with NATO Scientific Affairs Division."
Includes index
内容説明・目次
内容説明
This book of the proceedings of the 1997 NATO Advanced Study Institute (ASI) on Direct Methods for Solving Macromolecular Structures was assembled from the lecturers' contributions and represents a comprehensive and in-depth overview of crystallographic structure determination methods for macromolecules. While having a focus based on the direct methods, the Institute adopted an inclusive and broad perspective. Thus, both direct and experimental phasing techniques are presented in this book, highlighting their complementarities and synergies. As weil, methodologies spanning the full crystallographic image reconstruction process - from low resolution envelope definition to high resolution atomic refinement- are discussed. The first part of the book introduces the array of tools currently used in structure determination, whether originating from a mathematical, computational or experimental framework. This section of the book displays the variety and ingenuity of old and new phasing approaches developed to solve increasingly complex structures. Some of the contributions focus on recent developments and/or implementations that have given older approaches a new life. A case in point is the re-implementation of Buerger's superposition approach, which is now solving protein structures. Another beautiful example is found in the introduction to the traditional multiple isomorphous replacement approach where new techniques, such as site-directed mutagenesis and the use of inert gases in the preparation of heavy atom derivatives, are described. Equally impressive are the presentations of newer approaches, which take advantage of advances on the experimental front (e. g.
目次
Preface. 1. Introduction. 2. Tools for Solving the Phase Problem. 2.1. Mathematical Methods. 2.2. Computational Methods. 2.3. Experimental Methods. 3. Applications of Direct Methods to Macro-Molecular Structures. 3.1. Integration of Direct Methods with Experimental Phase Information. 3.2. Combining Direct Methods with Structural Information. 3.3 Ab Initio Phasing. 4. Latest Developments. Index.
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