Neocortical grafting to newborn and adult rats : developmental, anatomical and functional aspects
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Bibliographic Information
Neocortical grafting to newborn and adult rats : developmental, anatomical and functional aspects
（Advances in anatomy, embryology and cell biology, v. 148）
Springer, c1998
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Includes bibliographical references (p. 73-84) and index
Description and Table of Contents
Description
The first experiments with neural transplantation into the brain (for a review, see Bjorklund and Stenevi 1985) were reported at the end of the last century by Thompson (1890), who took cortical tissue from adult cats and implanted the tissue pieces into the neocortex of adult dogs. The neurons did not survive, but the transplanted mass did not disintegrate entirely. Successful graft ing into the brain was reported later by Ranson (1909), who implanted spinal ganglia into the cerebral cortex of developing rats, and by Dunn (1917), who reported survival of implanted neonatal cortex into the cortex of newborn recipients. Another important step was made by Le Gros Clark (1940) who reported that, in the rabbit, embryonic (E) cortical tissue could be successfully grafted into the cortex of young recipients. Ex periments by Wallace and Das (1982), and Bjorklund and Stenevi (1984), showing behavioral effects of grafts, subsequently stimu lated a growing interest in neurotransplantation research. Intrac erebral grafting is now considered a powerful tool for addressing fundamental questions about development, regenerative, or re storative phenomena in the central nervous system (CNS) and is a potential therapy for neurodegenerative diseases.
Table of Contents
1 Transplantation of Embryonic Cortex into Newborn Host Cortex: A Means to Study Neural Development.- 1.1 Introduction.- 1.2 Materials and Methods.- 1.2.1 Dissection and Preparation of the Graft Tissue.- 1.2.2 Transplantation of Tissues.- 1.2.3 Transplant Survival and Histology.- 1.2.4 Tract-Tracing Techniques.- 1.3 Early Specification of Neocortical Efferent Projections: The Homo- or Heterotopic Transplantation Paradigm.- 1.3.1 Development of Efferents from Frontally Placed Frontal or Occipital Transplants.- 1.3.1.1 Introduction.- 1.3.1.2 Results.- 1.3.1.3 Discussion.- 1.3.2 Development of the Spinal Cord Projection.- 1.3.2.1 Introduction.- 1.3.2.2 Materials and Methods.- 1.3.2.3 Results.- 1.3.2.4 Discussion.- 1.3.3 Development of the Tectal Projection.- 1.3.3.1 Introduction.- 1.3.3.2 Results.- 1.3.3.3 Discussion.- 1.4 Conclusion.- 2 Transplantation of Embryonic Cortex into the Damaged Cortex of Adult Rats.- 2.1 Introduction.- 2.2 Transplantation into the Frontal Cortex: Anatomical, Metabolic, and Behavioral Aspects.- 2.2.1 Anatomical Study: Transplant Efferents.- 2.2.1.1 Introduction.- 2.2.1.2 Materials and Methods.- 2.2.1.3 Results.- 2.2.1.4 Discussion.- 2.2.2 Metabolic Study: 2-Deoxyglucose Uptake.- 2.2.2.1 Introduction.- 2.2.2.2 Materials and Methods.- 2.2.2.3 Results.- 2.2.2.4 Discussion.- 2.2.3 Behavioral Study: Forelimb Usage.- 2.2.3.1 Introduction.- 2.2.3.2 Materials and Methods.- 2.2.3.3 Results.- 2.2.3.4 Discussion.- 2.2.4 Conclusion.- 2.3 Transplantation into the Occipital Cortex: Electrophysiological and Anatomical Aspects.- 2.3.1 Introduction.- 2.3.2 Materials and Methods.- 2.3.3 Results.- 2.3.3.1 Electrophysiological Observations.- 2.3.3.2 Anatomical Observations.- 2.3.4 Discussion.- 2.4 Conclusion.- 3 Summary.- 4 References.
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