The rat as animal model in breast cancer research : a histopathological study of radiation- and hormone-induced rat mammary tumors
Author(s)
Bibliographic Information
The rat as animal model in breast cancer research : a histopathological study of radiation- and hormone-induced rat mammary tumors
(Developments in oncology, 18)
M. Nijhoff, 1984
Available at 4 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
  Thailand
  United Kingdom
  Germany
  Switzerland
  France
  Belgium
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  United States of America
Note
Bibliography: p. 269-288
Includes index
Description and Table of Contents
Table of Contents
1 Introduction.- 1.1 Breast Cancer - An Overview.- 1.2 Purpose of the Study.- 2 Animals and Experimental Methodology.- 2.1 Rationale for Choice of Rat Strains.- 2.2 Origin of the Rats.- 2.3 Selected Biological Characteristics of the Rats.- 2.3.1 Growth Curves.- 2.3.2 Breeding Data.- 2.3.3 Selected Immunogenetic Data.- 2.4 Husbandry Conditions.- 2.5 Irradiation.- 2.6 Hormone Administration.- 2.7 Castration.- 2.8 Clinical Examination.- 2.9 Necropsy Procedures.- 2.10 Statistical Evaluation.- 3 Effects of Irradiation and Hormone Administration on Mammary Tumor Incidence.- 3.1 Introduction.- 3.2 Experimental Data.- 3.3 Crude Mammary Tumor Incidence Results.- 3.4 Dose-Effect Relationships.- 3.5 Conclusions.- 4 Normal Anatomy and Pathology of the Rat Mammary Gland.- 4.1 The Normal Mammary Gland.- 4.1.1 Anatomic Considerations.- 4.1.2 Histological Structure.- 4.1.3 Development.- 4.2 Pathological Changes - A Classification.- 4.3 Nonneoplastic Lesions.- 4.4 Neoplastic Lesions.- 4.4.1 Benign Mammary Tumors.- 4.4.2 Malignant Mammary Tumors.- 4.5 Histogenesis and Interrelationships of Certain Mammary Gland Lesions.- 4.6 Discussion.- 4.6.1 Histological Types of Rat Mammary Neoplasms.- 4.6.2 "Malignancy" of the Rat Mammary Carcinoma.- 5 Correlation of Mammary Tumor Histology with Experimental Procedures.- 5.1 Introduction.- 5.2 Tumor Types and Treatment Relationships.- 5.3 Topographical Distribution of Mammary Tumors.- 5.4 Discussion.- 6 Lesions of the Pituitary Gland and Liver.- 6.1 Introduction.- 6.2 Pituitary Gland.- 6.2.1 Background Remarks.- 6.2.2 Morphological Aspects.- 6.2.3 Effect of Irradiation and/or Estrogen Administration on Pituitary Tumor Incidence.- 6.2.4 Interrelationships Between Pituitary Tumors, Plasma Prolactin Levels and Mammary Tumors.- 6.2.5 Discussion.- 6.3 Liver.- 6.3.1 Background Remarks.- 6.3.2 Morphological Aspects.- 6.3.3 Results.- 6.3.4 Discussion.- 7 General Discussion, Including a Brief Review of Animal Models in Breast Cancer Research.- 7.1 Synthesis.- 7.2 Brief Review of Animal Models in Breast Cancer Research.- 7.2.1 Definition of an Animal Model.- 7.2.2 The Rat.- 7.2.3 The Mouse.- 7.2.4 The Dog.- 7.2.5 The Cat.- 7.2.6 Nonhuman Primates.- 7.2.7 Other Species.- 7.2.8 Conclusions.- Summary.- Acknowledgments.- References.
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