Monoclonal antibody therapy of human cancer
著者
書誌事項
Monoclonal antibody therapy of human cancer
（Developments in oncology）
Nijhoff , Distributors for North America, Kluwer Academic Publishers, c1985
大学図書館所蔵 件 / 全2件
-
該当する所蔵館はありません
- すべての絞り込み条件を解除する
注記
Includes bibliographies and index
内容説明・目次
内容説明
KENNETH A. FOON and ALTON C. MORGAN, JR. Passive immunotherapy using heteroantisera for the treatment of cancer in animals and humans has been studied for over 50 years. Attempts have been made to treat animal tumors with sera from immunized syngeneic, allogeneic, or xenogeneic animals. A number of studies of passive immunotherapy using heterologous antisera in humans have also been performed. These studies have generally been attempted in patients with large tumor burdens, and as would be expected, results have been transient at best. A wide variety of solid tumors as well as leukemias and lym- phomas have been treated with antisera raised in sheep, horses, rabbits, and goats. Problems such as anaphylaxis, serum sick- ness, and severe cytopenias have been encountered with these antisera. There are a number of potential mechanisms by which unconju- gated antibodies might be cytotoxic to tumor cells. Antibodies bound to the cell surface membrane of tumor cells may lead to cell lysis by complement-dependent or antibody-dependent cellu- lar cytotoxicity. Circulating tumor cells bound by antibody may be more susceptible to phagocytosis by the reticuloendothelial system.
Antibody bound to the cell surface membrane of tumor cells may enhance immunogenicity of the tumor cell leading to activation of the host's immune system.
目次
1. Monoclonal Antibody Therapy of Cancer: Parameters Which Affect the Efficacy of Immunotoxins.- 2. Design and Development of Drug-Monoclonal Antibody 791T/36 Conjugate for Cancer Therapy.- 3. Monoclonal Antibodies Directed Towards Growth-Related Receptors on Human Tumors.- 4. Monoclonal Antibody Therapy for Patients with Leukemia and Lymphoma.- 5. Monoclonal Antibody Therapy of Solid Tumors.- 6. Human Immune Responses to Murine Monoclonal Antibodies.- 7. Radiolabeled Monoclonal Antibodies for Imaging and Therapy.
「Nielsen BookData」 より