Hepatocyte transplantation
著者
書誌事項
Hepatocyte transplantation
Karger Landes Systems, c1997
- hardcover
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
The rapidly increasing frequency of organ transplantation is causing a severe shortage of donor organs. Hepatocyte transplantation has thus been studied to develop an alternative therapeutic method for patients with various liver diseases. In experimental studies using rodents, transplanted hepatocytes survive and function in ectopic sites for a long period of time. Recent advances in molecular biology and tissue engineering enable us to manipulate isolated hepatocytes before transplantation. Before clinical application of this new therapeutic method, there are many issues to be resolved such as determining an optimal location for transplantation, rapid proliferation of transplanted hepatocytes, transplantation in large animals, immunological reactions and long-term gene expression. In this book, authorities on hepatocyte transplantation from all over the world describe progress in this field and discuss the unsolved problems. For researchers and clinicians interested in the liver, this book will be the definitive resource on hepatocyte transplantation.
目次
- Historical review of hepatocyte transplantation
- hepatocyte preparation and preservation
- routes for hepatocyte transplantation
- long-term survival of transplanted hepatocytes
- proliferation of transplanted hepatocytes
- hepatocyte transplantation for liver disorders
- immunological problems
- gene transfection
- hepatocyte transplantation in large animals and humans.
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