Antisense oligodeoxynucleotides and antisense RNA : novel pharmacological and therapeutic agents
著者
書誌事項
Antisense oligodeoxynucleotides and antisense RNA : novel pharmacological and therapeutic agents
（Pharmacology & toxicology）
CRC Press, c1997
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
The use of antisense strategies in modifying biological events signals a new era of pharmacotherapy. Antisense oligodeoxynucleotides and antisense RNA allow pharmacologists to design agents that are more predictable and selective in their actions. This book is a practical, state-of-the-art treatise on antisense oligodeoxynucleotide and antisense RNA technology and the potential application of these strategies in therapeutics. It describes both the advances and setbacks experienced in studying this revolutionary field of study. Critical analyses of the specificity of the agents are featured, and the possibility of antisense oligomers acting through non-antisense mechanisms is considered.
Antisense Oligodeoxynucleotides and Antisense RNA: Novel Pharmacological and Therapeutic Agents covers these important topics:
History of the early development of antisense oligodeoxynucleotides
How oligodeoxynucleotides have been chemically modified to increase their stability, delivery, and penetration into cells
Pharmacokinetic properties of antisense oligodeoxynucleotides
Non-antisense effects of antisense oligonucleotides
In vitro and in vivo model systems
Results of early clinical trials and the potential of agents for treating certain clinical disorders
The use of antisense oligodeoxynucleotides to study reproductive behavior, pain perception, hypertension, and cancer
The use of non-viral and viral expression vectors that encode antisense RNA sequences and their potential therapeutic applications in treating disorders involving abnormal cell growth, in inhibiting replication of HIV, and in treating a variety of neurobiological disorders
目次
Historical Aspects of Antisense Oligodeoxynucleotides, J.-J. Toulme
Advances in Understanding the Pharmacological Properties of Antisense Oligonucleotides, S. Crooke
Pharmacokinetics of Phosphorothioate Oligonucleotides and its Novel Analogs, S. Agrawal and R. Zhang
Non-Antisense Effects of Antisense Oligonucleotides, L.M. Neckers and K. Iyer
Use of Antisense Oligodeoxynucleotides to Modulate Reproductive Behavior, M.M. McCarthy
Establishing the Molecular Biology of Opioid Behavior through Antisense Approaches, G.C. Rossi and G.W. Pasternak
Antisense Oligodeoxynucleotides Targeted to the Angiotensin System as a Novel Strategy to Treat Hypertension, M.I. Philips and R. Gyurko
Antisense DNA Therapy of Burkitt's Lymphoma in Em-myc Transgenic Mice, E. Wickstrom
Regulating Genes with Antisense RNA, J. Oberstrass and W. Nellen
Development of Retroviral Vectors Expressing Antisense RNA to Inhibit Replication of the Human Immunodeficiency Virus, B.A. Bunnell and R. Morgan
Use of Plasmid Antisense RNA Expression Vectors to Alter Neurobiological Effects, G. Davidkova, S.-P. Zhang, L.-W. Zhou, R.A. Nichols, and B. Weiss
Index
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