書誌事項

Tailored polymeric materials for controlled delivery systems

Iain McCulloch, editor, Shalaby W. Shalaby, editor

(ACS symposium series, 709)

American chemical Society, c1998

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注記

"Developed from a symposium sponsored by the Division of Polymer Chemistry at the 214th National Meeting of the American Chemical Society, Las Vegas, Nevada, September 7-11, 1997."

Includes bibliographical references and index

内容説明・目次

内容説明

The molecular engineering design and application of polymeric materials for use in delivery systems has evolved into one of the most promising advanced technology areas of polymer science as well as contemporary medical, pharmaceutical, and agricultural science. This volume opens with two chapters providing a perspective on current topics in the field. The remaining twenty-two chapters discuss new and innovative research in the area. They emphasize the role of molecular architecture and associated design and synthesis of new chain molecules and also cover assembling strategies for modulation of release profiles. The authors provide concise accounts of key administration routes and clinical applications. Topics include nanosphere micelles, microspheres, solid implants and injectable liquid gel-formers.

目次

  • CRITICAL REVIEWS
  • 1. Intravitreal treatment of cytomegalovirus retinitis and the need for controlled release systems
  • 2. Key features and future perspectives in the development of intravaginal drug delivery systems
  • MOLECULAR DESIGN OF POLYMERIC CARRIERS
  • 3. Cationic hydrogels for controlled release of proteins and other macromolecules
  • 4. Water soluble polyanions as oral drug carriers: poly(sulfopropyl methacrylate potassium-co-alkyl methacrylate)
  • 5. Polymer prodrugs with pharmaceutically active degradation products
  • 6. Synthesis of thioester end-functionalized poly-(e-caprolactone) and its application in chemselective ligation
  • 7. The "reactive polymer micelle", convenient tool for targeting drug delivery system
  • 8. Hyperbranched polymeric micelles: drug encapsulation, release, and polymer degradation
  • 9. Injectable absorbable gel-formers for the controlled release of bioactive agents/drugs
  • 10. Novel ionogenic acrylate copolymer networks for sustained solute delivery
  • 11. Direct synthesis of polyester microspheres, potential carriers of bioactive compounds
  • STRATEGIES TO MODULATING AND MONITORING THE RELEASE PROFILE
  • 12. Novel bioadhesive complexation networks for oral protein drug delivery
  • 13. Shell Corss-linked knedels: amphiphilic core-shell nanospheres with unique potential for controlled release application
  • 14. Multilayered semicrystalline polymeric controlled release systems
  • 15. Electroconductive gels for controlled electrorelease of bioactive peptides
  • 16. A new approach to in-situ thermal gelation of alginate for controlled release
  • 17. Effect of surfactants on the release of grisefulvin from polyvinylpyrrolidone dispersions
  • 18. Self diffusion of solvents and solute probes in polymer solutions and gels as studied by pulsed-gradient NMR spectroscopy: the use of a new physical model of diffusion
  • 19. Biodegradation of poly(lacic-co-glycolic acid) oligomers
  • 20. Poly(lactic-co-glycolic acid) oligomeric micro0granules for asprin delivery and stabilization
  • 21. Antitumor drug delivery by dextran derivatives immobilizing platinum complex (II) through coordination bond
  • 22. Potential role of controlled drug delivery in tissue engineering
  • 23. Direct measurement of mulitphase flow using controlled release of polymers soluble in single phase
  • 24. Structural characterization and effects of gibberellic acid-containing organotin polymers on sawgrass and cattail germination and seedling growth for everglades restoration

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