Brain and biodefence
著者
書誌事項
Brain and biodefence
（Taniguchi symposia on brain sciences, no. 21）
Japan Scientific Societies Press , Tokyo : Karger, c1998
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内容説明・目次
内容説明
Since neural-immune interaction was recognized as a discipline in the late 1970s, there has been mushrooming growth in this field of research. This book covers the major areas of interest and current research in the biology of neuroimmunomodulation: The brain and the immune system communicate with each other by sharing signal molecules and receptor mechanisms. The topics of research devoted to the interaction between the two systems can essentially be itemized as follows: 1. How the brain modulates the immunity by controlling the endocrine system and the innervations on the immunological organs. 2. How the immune system signals the brain and thereby modulates the activities of the neural and endocrine systems. 3. How and to what extent these bidirectional interactions contribute to the physiology and pathology of the organisms. In this book these interactions are analyzed at all levels. Consequently, research in this field incorporates a variety of disciplines including neurophysiology, endocrinology, immunology, anatomy, biochemistry, pharmacology and clinical medicine. The rate of advancement has also been greatly accelerated by newly refined modern substances working in neural, endocrine and immune tissues.
目次
- Part 1 Neuroendocrine control of immunity: hypothalamic modulation of delayed-type hypersensitivity and splenic natural killer cell activity
- neuroendocrine regulation of Th1/Th2 balance
- sympathetic modulation of immunity in ageing
- effects of pituitary adenylate cyclase activating polypeptide on phagocytosis and membrane current of mouse peritoneal macrophages and microglia. Part 2 Actions of cytokines on neural and endocrine functions: actions of aFGF in senescence-accelerated mice - protective effects against deficits of learning and memory, effects on immunological functions
- cytokines and acute brain injury - focus on IL-1, IL-10 and TGFbeta
- immune and autoimmune responses in transgenic mice expressing IL-12 in astrocytes
- neuroendocrine and immune dysfunctions in GRGR1-deficient mice. Part 3 How the immune system signals the brain: role of brain endothelial cyclooxygenase-2 in the transmission of immune signal to the central nervous system
- CNS responses to immune system challenge - mechanisms of the febrile response
- brain cytokine expression in response to peripheral infection
- bagal afferent nerve mediates immune signals to the brain. Part 4 Stress and immunity: non-inflammatory stress and brain-gut-liver-immune axis
- neuroendocrine regulation of the immune repsonse - contrasting effects of physical and social stress
- stress induces neuronal damage in the hippocampus and dopaminergic dysfucntions in the prefrontal cortex in rats. Part 5 Neurtrophic and neurotoxic functions of cytokines: interleukin-3 as a neurotrophic factor for central cholinergic neurons - the function of interleukin-3 in perspectives on neural immune interactions
- caspases in developmental neuronal death and ischemic brain injury
- pathophysiological significance of cytokine network in the brain
- microglia and immunity in relation to Alzheimer's disease.
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