The development of human gene therapy
著者
書誌事項
The development of human gene therapy
（Cold Spring Harbor monograph series, 36）
Cold Spring Harbor Laboratory, c1999
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This text chronicles the evolution of human gene therapy, illustrating how imaginative concepts shaped the development of technologies. It should be of interest to those interested in clinical medicine, biotechnology and the biology of gene transfer.
目次
- The origins, evolution and directions of human gene therapy
- retroviral vectors
- lentiviral vectors
- structure and genetic organization of adenovirus vectors
- adenovirus vectors
- strategies to adapt adenoviral vectors for gene therapy applications - targeting and integration
- adeno-associated viral vectors
- gene-transfer tool - herpes simplex virus vectors
- emerging viral vectors
- advances in synthetic gene-delivery system techology
- receptor-mediated gene delivery strategies
- naked DNA gene transfer in mammalian cells
- delivery systems and adjuvants for DNA vaccines
- targets for gene therapy
- the haemotopoietic system as a target for gene therapy
- cancer immunotherapy
- gene transfer and stem-cell transplantation
- suicide genes - gene therapy applications using enzyme/prodrug strategies
- the logic of anti-angiogenic gene therapy
- apoptosis as a goal of cancer gene therapy
- advances in gene therapy for HIV and other viral infections
- progress toward gene therapy for nervous system diseases
- targeted gene repair in mammalian cells using chimeric RNA/DNA oligonucleotides
- human gene therapy - public policy and regulatory issues
- ethical issues in human gene transfer research.
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