Neuropeptides : regulators of physiological processes

著者

書誌事項

Neuropeptides : regulators of physiological processes

Fleur L. Strand

（Cellular and molecular neuroscience series）

MIT Press, c1999

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注記

"A Bradford book."

Includes bibliographical references and index

内容説明・目次

内容説明

This textbook is the first to bring together and synthesize the neuropeptide research of the past decade in such a comprehensive, scholarly manner. In recent years there has been increasing interest and, subsequently, active research in neuropeptides. These neuroactive molecules coordinate, integrate, and regulate physiological processes in all organisms, throughout all phases of development. Acting as neurohormones, neurotransmitters, and/or neuromodulators, they maintain physiological homeostasis and influence important behavioral patterns. This textbook is the first to bring together and synthesize the neuropeptide research of the past decade in such a comprehensive, scholarly manner. The book is divided into two parts. In Part I the author defines the basic principles of neuropeptide action, including their biosynthesis, processing, transport, distribution, and interactions with receptors and second messenger systems. Strand also discusses the intimate interaction between the neuropeptides, stress, and the immune system. In Part II she discusses the regulatory functions of the families of neuropeptide in sufficient detail to provide both the advanced student and senior investigator with a thorough understanding of the most important neuropeptides. The text also contains a complete and up-to-date reference/reading list.

目次

  • Part 1 General characteristics of neuropeptides: the neuropeptide concept and the evolution of neuropeptides
  • methods of studying neuropeptides
  • biosynthesis, processing, secretion and inactivation of neuropeptides
  • distribution and localization of neuropeptides
  • the neuroendocrine system and the transport of neuropeptides
  • neuropeptide receptors as regulators of cellular functions
  • neuropeptides as neurotransmitters, neuromodulators and neurohormones
  • neuropeptides, stress and the immune system. Part 2 Neuropeptide families - the regulatory role of neuropeptides: characteristics of hypothalamic regulatory neuropeptides
  • hypophysiotropic neuropeptides - TRH, CRH, GnRH, GHRH, SS, PACAP, DSIP
  • hypothalamic-neurohypophyseal hormones - VP and OT
  • anterior pituitary neuropeptides 1 - the POMC-derived neuropeptides - ACTH, MSH, -LPH, -EP
  • anterior pituitary neuropeptides 2 - the glycoprotein and growth hormone families - secretoneurin
  • endogenous opiate neuropeptides - endorphins, enkephalins, dynorphins, Tyr-MIF-1 and nociceptin
  • tachykinins - substance P, neurokinin A and neurokinin B
  • gut and brain neuropeptides 1 -neuropeptide families - gastrin/CCK, VIP/secretin/glucagon, PP/PYY/NPY, BN/GRP
  • gut and brain neuropeptides 2 - insulin, galanin, motilin, CGRP, neurotensin
  • cardiac, renal, parathyroid and thyroid neuropeptides - ANH, AT, Ct, PTH, PTH-rP, T3, T4
  • invertebrate neuropeptides.

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