Cellular responses to stress
著者
書誌事項
Cellular responses to stress
（Biochemical Society symposium, no. 64）
Portland, c1999
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注記
Includes bibliographies and index
内容説明・目次
内容説明
This volume provides information on the wide spectrum of mechanisms which cells from simple prokaryotes to man use to respond to different forms of stress induced by chemicals, oxidants and DNA damaging agents. These mechanisms are fundamental to human health because they are crucial to the sensitivity of micro-organisms to chemotherapeutic agents, and they determine the sensitivity of normal and tumor cells to environmental agents and anti-cancer drugs. Research on these pathways is providing a wealth of new targets from which novel therapeutic agents are likely to emerge. This book brings together some of the world's top scientists who work in different, but interrelated aspects of cellular responses. They bring together aspects of the subject which in the past have been regarded independently. The spectrum of topics is covered so as to provide a broad overview of our current knowledge of the different forms of adaptive response systems. The book should be valued by research workers at all levels from senior academics to postgraduates and should also appeal to senior undergraduates undertaking specialized research projects.
In addition, the book should be valuable to industrial scientists in the pharmaceutical and biotechnology industries and to researchers at the clinical interface.
目次
- Signal transduction by the c-Jun N-terminal kinase
- roles of the AMP-activated/SNF1 protein kinase family in the response to cellular stress
- making the connection - coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses
- stress-activated MAP kinase (mitogen-activated protein kinase) pathways of budding fission yeasts
- protein kinase cascades in intracellular signalling by interleukin-1 and tumor necrosis factor
- regulation of actin dynamics by stress-activated protein kinase 2 (SAPK2)-dependent phosphorylation of heat-shock protein of 27/kDa (Hsp27)
- DNA-dependent protein kinase and related proteins
- stress-induced activation of the heat-shock response - cell and molecular biology of heat-shock factors
- transcriptional regulation via redox-sensitive iron-sulphur centres in an oxidative stress response
- adaptive responses to environmental chemicals
- cellular response to cancer chemopreventive agents - contribution of the antioxidant repsonsive element to the adaptive response to oxidative and chemical stress.
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