Cell cycle regulation
Author(s)
Bibliographic Information
Cell cycle regulation
（New horizons in therapeutics, 1）
Harwood Academic, 1997
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Note
Includes bibliographies and index
Description and Table of Contents
Description
Focuses on recent key discoveries made relating to the cell cycle and its regulation - a critical new horizon in therapeutics.
Research into all aspects of cell cycle regulation has undergone explosive growth during the past decade due to the powerful techniques of molecular biology. An overall view of the cellular processes, both at the enzymatic and genetic level, has been identified in continually finer detail, as described inside this text. This has enabled significant progress in the identification of drugs capable of acting on specific components of the cell cycle, with the result that we may soon have the ability to manipulate the cell cycle pharmacologically. The potential impact on clinical conditions such as cancer, hematopoiesis, angiogenesis, inflammation, organ remodelling and apoptosis is vast.
Originating from presentations at the Eighth SmithKline Beecham Pharmaceuticals United States Research Symposium, each chapter in this volume is written by an opinion leader in the field.
Table of Contents
1. Cell Cycle Regulation in Hematopoietic Stem Cells 2. Complex Regulation of the NF-KB Transcription Factor Complex: NF-KB Activation Is Inhibitable by Tyrosine Kinase Inhibitors 3. Signalling by the Cytokine Receptor Superfamily 4. Cytokine Driven Signal Transmission 5. The pp70S6k Signalling Pathway Is Activated by a Complex Multistep 6. Process Involving Several Signalling Pathways 7. Biochemical Dissection of Nuclear Events In Apoptosis 8. Angiogenesis and the Endothelial Cell Cycle 9. Regulation of Inflammatory Cytokine Biosynthesis: Discovery of a Low Molecular Weight Inhibitor and Its Molecular Target 10. Bcl-2 Family Proteins in Cancer: Regulators of Cell Death Involved in Resistance to Therapy 11. Coupled Control of Cell Proliferation and Cell Viability by Oncogenes and Cytokines
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