Principles of protein x-ray crystallography
Author(s)
Bibliographic Information
Principles of protein x-ray crystallography
（Springer advanced texts in chemistry / Charles R. Cantor, editor）
Springer, c1999
2nd ed
Available at 39 libraries
Note
Includes bibliographical references and index
Description and Table of Contents
Description
X-ray crystallography has been a vital method for studying the structure of proteins and other macromolecules for many years. As the importance of proteins continues to grow in a wide range of research fields from basic biochemistry and biophysics to pharmaceutical development and biotechnology, more and more researchers have found a knowledge of X-ray diffraction to be an indispensable tool. Professor Drenth, recognized internationally for his numerous contributions to crystallographic research, has provided a technically rigorous introduction to the subject. This book provides the theoretical background necessary to understand how the structure of proteins is determined at atomic resolution. It is intended to be an introduction for graduate students, postdoctoral researchers, and established scientists who want to apply protein crystallography in their own endeavors, or need to understand the subject in order to critically evaluate the literature. "Principles of Protein X-ray Crystallography" is appropriate as a textbook for courses in biochemistry and biophysics, including protein structure and function, structural biology, and macromolecular structure.
Table of Contents
Crystallizing a Protein X-ray Sources and Detectors Crystals The Theory of X-ray Diffraction by a Crystal Average Reflection Intensity and Distribution of Structure Factor Data Special Forms of the Structure Factor The Solution of the Phase Problem by the Isomorphous Replacement Method Phase Improvement Anomalous Scattering in the Determination of the Protein Phase Angles and the Absolute Determination Molecular Replacement Direct Methods Laue Diffraction Refinement of the Model Structure The Combination of Phase Information Checking for Gross Errors and Estimating the Accuracy of the
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