Gap junction-mediated intercellular signalling in health and disease
著者
書誌事項
Gap junction-mediated intercellular signalling in health and disease
（Novartis Foundation symposium, 219）
Wiley, c1999
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注記
Organizer and editor: Gail Cardew
Includes bibliographical references and index
内容説明・目次
内容説明
Gap junction-mediated communication is essential for normal embryonic development and function in adult organs. Highlighting the progress in understanding gap junction structure, this concise volume discusses the specific roles of individual connexins (gap junction proteins). It brings together an interdisciplinary group of experts, who review the role of gap junctions in cell proliferation and cancer, the retina and lens, the auditory system, the heart, the central and peripheral nervous system, and the reproductive system.
目次
- Molecular biology, gene expression and regulation of gap junctions
- electron cryo-crystallography of a recombinant gap junction channel at 7 resolution - progress towards visualizing different conformational states
- trafficking and assembly
- interactions between growth factors and gap junctional communication in developing systems
- biological functions of gap junctions revealed by genetic defects, targeted mutations and dominant negative approaches
- connexins in the lens - are they to blame in diabetic cataractogenesis?
- neuronal coupling in the central nervous system - lessons from the retina
- gap junctions and connexin expression in the inner ear
- gap junctions and connexin expression in the adult and developing cerebral cortex
- peripheral nervous system (Charcot-Marie-Tooth disease)
- cardiovascular disease
- misregulation of Connexin43 (1) gap junction channels and congenital heart defects
- use of dominant negative, antisense and targeted gene disruption strategies for the study of gap junction function
- connexins in tumour suppression and cancer therapy.
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