Drug discovery from nature
著者
書誌事項
Drug discovery from nature
Springer, c1999
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This book is unique in covering the present status and future potential of natural products in drug discovery. It provides readers with recent information regarding the impact on drug discovery, development and strategies, technical and automation aspects, and methods based on biochemistry as well as molecular biology, highlighting compounds from natural sources. Special emphasis is placed on the various strategies to gain access to natural compounds and combinatorial approaches by making use of both synthetic and biological methods.
目次
The Impact of Natural Products on Drug Discovery.- Recent Developments in Drug Discovery Technologies.- A Central Natural Product Pool: New Approach in Drug Discovery Strategies.- Automation Strategies in Drug Discovery.- Synergistic Use of Combinatorial and Natural Product Chemistry.- Supercritical Fluid Extraction - Novel Strategies in the Processing of Biomaterials.- Secondary Metabolites: From Past to Present.- The Chemical Screening Approach.- Myxobacteria as Producers of Secondary Metabolites.- Trends in Marine Biotechnology.- Structure Modification via Biological Derivation Methods.- Molecular Biological Aspects of Antibiotic Biosynthesis.- Combinatorial Biosynthesis of Antibiotics.- Impact of Natural Products on Cell Biology: Low-Molecular Mass Effectors of Folding Helper Enzyme.- Novel Antibacterial Drugs from Microorganisms.- New Antibiotics with Novel Mode of Action.- Synthetic Combinatorial Libraries: A New Tool for Antimicrobial Agent Discovery.- Strobilurins and Oudemansins.
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