Cerebral ischemia : molecular and cellular pathophysiology
著者
書誌事項
Cerebral ischemia : molecular and cellular pathophysiology
（Contemporary neuroscience）
Humana Press, c1999
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
The human brain represents about 2% of the body weight, yet it accounts for approximately 20% of aerobic metabolism. This high dependency on energy-consuming processes is mainly caused by the active transport of ions, which is necessary to compensate for the transmembrane ion currents that are part ofthe complex signaling processes in the brain. Ninety-five percent ofthe brain's ATP is derived from mitochondrial oxidative phosphorylation. Since that organ' s storage capacity for oxygen is minimal, any interruption of oxygen delivery to brain cells willlead to changes in membrane excitability and, there fore, to disruption of neuronal signaling within seconds. It seems that mamma lian brain is especially vulnerable to such an interruption, since oxygen deprivation leads to activation of ion channel mechanisms in neurons that impair their communications. Thus, the function of the brain as a coordinator of vital homeostatic reflexes, and complex body reactions to external challenges, depends critically on the rate of oxygen delivery and oxygen consumption. Oxygen delivery depends on two variables described in the Fick relation ship: volume flow rate ofblood and the arterial oxygen content. A reduction in either of these two variables will have serious effects on vital brain func tions. Reduction of arterial blood flow to the brain can be caused by cardiac arrest, shock, carotid occlusion, Of hypotension (global ischemia). Oxygen content is progressively decreased in asphyxia (including drowning).
目次
Part I. Overview. Mechanisms of Cerebral Ischemic Damage, Costantino Iadecola. Part II. Factors in the Brain Microenvironment. Spreading Depression Waves as Mediators of Secondary Injury and of Protective Mechanisms, Anna Irwin and Wolfgang Walz. Cell Swelling in Cerebral Ischemia, Harold K. Kimelberg. Calcium Overload, Paul Morley, Joseph S. Tauskela, and Antoine M. Hakim. Oxygen Radicals, Pak H. Chan. Mechanisms of Neuroprotective Cytokines: Pleiotrophic Effects of TNFa and TGFb on Brain Injury, Annadora J. Bruce-Keller and Mark P. Mattson. Part III. Cellular Changes. Reprogramming of Gene Expression After Ischemia,Thaddeus S. Nowak, Jr. and Marika Kiessling. Neurons: Necrotic vs Apoptotic Changes, Koji Abe. Reactive Astrogliosis in the Injured and Postischemic Brain, Ronald Jabs, Lane K. Bekar, and Wolfgang Walz. Activated and Phagocytic Microglia,Yoichi Kondo. Index.
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