Endothelin receptors and signaling mechanisms
著者
書誌事項
Endothelin receptors and signaling mechanisms
（Molecular biology intelligence unit）
R.G. Landes , Springer, 1998
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This work focuses on the wide variety of events that occur as a result of endothelin receptor activation. This includes a discussion of the various pathways by which endothelin activates Ca2+ signals from several intra- and extra-cellular sources and the effects of endothelin on ion channels and membrane function. In addition, the mechanisms by which endothelin influences the ion transport within the renal epithelium are covered, as well as the signal transduction pathways activated by endothelin in both cardiac tissue and vascular smooth muscle.
目次
1. Introduction to the Endothelin System.- 2. Endothelin Receptors and Receptor Antagonists.- 3. Novel Endothelin Receptors.- 4. "Sticky" Conundrums in the Endothelin System: Unique Binding Characteristics of Receptor Agonists and Antagonists.- 5. Functional Coordination and Cooperation Between Endothelin and Nitric Oxide Systems in Vascular Regulation.- 6. Molecular and Structural Biology of Endothelin Receptors.- 7. Cytokine Regulation of Endothelin Action.- 8. Endothelin Modulation of Renal Sodium and Water Transport.- 9. Endothelin and Ion Channels.- 10. Endothelin and Calcium Signaling.- 11. Endothelin Regulation of Cardiac Contractility: Signal Transduction Pathways.- 12. Endothelin Signaling to the Nucleus: Regulation of Gene Expression and Phenotype.- 13. Mechanisms of Endothelin-induced Mitogenesis and Activation of Stress Response Protein Kinases.- Color Insert.
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