Vitamin D : molecular biology, physiology, and clinical applications
Author(s)
Bibliographic Information
Vitamin D : molecular biology, physiology, and clinical applications
（Nutrition and health）
Humana Press, c1999
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Note
Includes bibliographical references and index
Description and Table of Contents
Description
A comprehensive, highly readable overview of the biological functions and clinical applications of vitamin D and its metabolites. Topics range from the most recent recommendations for vitamin D intake to new approaches for the treatment and prevention of vitamin D deficiency and the development of active vitamin D drugs to treat psoriasis and cancer. The book authoritatively reviews the relationship between sunlight exposure, vitamin D, and increased risk of colon and breast cancer; how vitamin D is made in the skin; and the sequence of events that leads to its activation by the kidney. Also examined are the biological functions of 1,25-dihydrovitamin D3 on the intestine and bone, as well as other tissues, such as skin, the immune system, prostate, and breast, and vitamin D's molecular mechanism of action on the cell membrane and nucleus. Vitamin D: Physiology, Molecular Biology, and Clinical Applications will serve as an authoritative day-to-day source for all those health care professionals, internists, dermatologists, house staff, and basic scientists who seek today's clearest understanding of the broad role of vitamin D in human health.
Table of Contents
Evolution, Biologic Functions, and Recommended Dietary Allowances for Vitamin D.- Photobiology of Vitamin D.- Functional Metabolism and Molecular Biology of Vitamin D Action.- Metabolism and Catabolism of Vitamin D, Its Metabolites, and Clinically Relevant Analogs.- The Enzymes Responsible for Metabolizing Vitamin D.- The Vitamin D Binding Protein and Its Clinical Significance.- Molecular Biology of the Vitamin D Receptor.- Vitamin D Receptor Translocation.- Molecular Recognition and Structure-Activity Relations in Vitamin D-Binding Protein andVitamin D Receptor.- Mechanisms of Action of 1,25-Dihydroxyvitamin D3 on Intestinal Calcium Absorption and Renal Calcium Transport.- Biologic and Molecular Effects of Vitamin D on Bone.- Nongenomic Rapid Effects of Vitamin D.- Noncalcemic Actions of 1,25-Dihydroxyvitamin D3 and Clinical Implications.- Regulation of Parathyroid Hormone Gene Expression and Secretion by Vitamin D.- Vitamin D Assays and Their Clinical Utility.- Rickets and Vitamin D Deficiency.- Vitamin D and Bone Health in Adults and the Elderly.- Inherited Defects of Vitamin D Metabolism.- Molecular Defects in the Vitamin D Receptor Associated with Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets.- Extrarenal Production of 1,25-Dihydroxyvitamin D and Clinical Implications.- Clinical Utility of 1,25-Dihydroxyvitamin D3 and Its Analogs for the Treatment of Psoriasis and Other Skin Diseases.- Epidemiology of Cancer Risk and Vitamin D.- Chemotherapeutic and Chemopreventive Actions of Vitamin D3 Metabolites and Analogs.- Vitamin D and Breast Cancer.- Anticancer Activity of Vitamin D Analogs.
by "Nielsen BookData"