Polymorphism in pharmaceutical solids
著者
書誌事項
Polymorphism in pharmaceutical solids
（Drugs and the pharmaceutical sciences, v. 95）
M. Dekker, c1999
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
"Presents a comprehensive examination of polymorphic behavior in pharmaceutical development-demonstrating with clear, practical examples how to navigate complicated crystal structures. Edited by the recipient of the American Association of Pharmaceutical Scientists' 1998 Research Achievement Award in Analysis and Pharmaceutical Quality."
目次
- Theory and origin of polymorphism
- application of the phase rule to the characterization of polymorphic systems
- structural aspects of polymorphism
- structural aspects of hydrates and solvates
- generation of polymorphs, hydrates, solvates and amorphous solids
- methods for the characterization of polymorphs and solvates
- effects of polymorphism and solid-state solvation on solubility and dissolution rate
- effects of pharmaceutical processing on drug polymorphs and solvates
- structural aspects of molecular dissymmetry
- impact of polymorphism on the quality of lyophilized products.
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