Polymorphism in pharmaceutical solids

Bibliographic Information

Polymorphism in pharmaceutical solids

edited by Harry G. Brittain

(Drugs and the pharmaceutical sciences, v. 95)

M. Dekker, c1999

Available at  / 10 libraries

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Note

Includes bibliographical references and index

Description and Table of Contents

Description

"Presents a comprehensive examination of polymorphic behavior in pharmaceutical development-demonstrating with clear, practical examples how to navigate complicated crystal structures. Edited by the recipient of the American Association of Pharmaceutical Scientists' 1998 Research Achievement Award in Analysis and Pharmaceutical Quality."

Table of Contents

  • Theory and origin of polymorphism
  • application of the phase rule to the characterization of polymorphic systems
  • structural aspects of polymorphism
  • structural aspects of hydrates and solvates
  • generation of polymorphs, hydrates, solvates and amorphous solids
  • methods for the characterization of polymorphs and solvates
  • effects of polymorphism and solid-state solvation on solubility and dissolution rate
  • effects of pharmaceutical processing on drug polymorphs and solvates
  • structural aspects of molecular dissymmetry
  • impact of polymorphism on the quality of lyophilized products.

by "Nielsen BookData"

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