Freeze-drying/lyophilization of pharmaceutical and biological products
Author(s)
Bibliographic Information
Freeze-drying/lyophilization of pharmaceutical and biological products
(Drugs and the pharmaceutical sciences, v. 96)
M. Dekker, c1999
- hbk.
Available at 6 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
  Thailand
  United Kingdom
  Germany
  Switzerland
  France
  Belgium
  Netherlands
  Sweden
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  United States of America
Note
Includes bibliographical references and index
Description and Table of Contents
Description
Highlights the application of freeze-drying to pharmaceuticals, illustrating practical and industry-tested methods of preserving and reactivating delicate biologicals and biochemicals. The text discusses the basic principles and engineering aspects of lyophilization, and also the role of bulking agents, cryoprotectants, antioxidants, free radicals, and other products that protect the biological integrity of active substances during freezing, drying and storage.
Table of Contents
- Glimpses into the realm of freeze-drying - classical issues and new ventures
- potential energy surfaces, computer simulations, and the structure of water
- structural and dynamic properties of bulk and confined water
- experimental freeze-drying procedures and equipment
- freezing and drying-induced perturbations of protein structure and mechanisms of protein protection by stabilizing additives
- mechanisms of protein stabilization during freeze-drying and storage - the relative importance of thermodynamic stabilization and glassy state relaxation dynamics
- the regulatory control of freeze-dried products - importance and evaluation of residual moisture
- basic aspects and industrial strategies for the preservation of microorganisms by freezing and drying
- industrial freeze-drying for pharmaceutical applications
- industrial freeze-drying of vaccines destined for veterinary purposes - an overview
- manufacturing principles of freeze-dried collagen sponges - characteristics and applications
- lyophilization process validation
- critical steps in the preparation of elastomeric closures for biopharmaceutical freeze-dried products
- technical procedures for operation of cleaning in place and sterilization in place process for production freeze-drying equipment
- studies on the development of manufacturing processes for pharmaceutical freeze-dried products
- potential prospects in freeze-drying.
by "Nielsen BookData"