Stereoselectivity in synthesis

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Bibliographic Information

Stereoselectivity in synthesis

Tse-Lok Ho

(A Wiley-Interscience publication)

J. Wiley, c1999

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Includes bibliographical references and index

Description and Table of Contents

Description

Many chemicals are found in "right-" and "left-handed" forms that may react differently in the body. In planning a synthesis, chemists must know how to select the best method for making the preferred form of a chemical. This book shows how to choose the best method for a given synthesis. It provides readers with a thorough understanding of stereoselectivity in organic and medicinal chemistry as well as the pharmaceutical, agricultural, and food industries.

Table of Contents

Some Fundamental Concepts. 1,2-Stereoinduction. 1,3-Stereoinduction. Stereoinduction at Long Distances. Group Directed Reactions and Chelation Effects. Conformational Effects. Topographical and Template Effects. Steric, Electrostatic, and Stereoelectronic Effects. Thermodynamic Control and Kinetic Trapping. Index.

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