A means to an end : the biological basis of aging and death
著者
書誌事項
A means to an end : the biological basis of aging and death
Oxford University Press, 1999
- :pbk
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注記
Includes bibliographical references (p. [221]-228) and index
内容説明・目次
- 巻冊次
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ISBN 9780195125931
内容説明
This work covers ageing from a fundamental cell biological perspective. The evolution and developmental genetics of senescence are explained clearly. All the various theories of ageing - the Hayflick limit and telomeric shortening as a possible biological clock, the impacts of somatic mutations, oxidative stress, accumulation of waste materials in cells with age - are explained and critically assessed. The author presents vivid case accounts about disorders that open windows on to the ageing process. The impacts of ageing on the brain and nervous system are given special attention, as are the effects of caloric restriction on maximum lifespan.
- 巻冊次
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:pbk ISBN 9780195153750
内容説明
Why do we age? Is aging inevitable? Will advances in medical knowledge allow us to extend the human lifespan beyond its present limits? Because growing old has long been the one irreducible reality of human existence, these intriguing questions arise more often in the context of science fiction than science fact. But recent discoveries in the fields of cell biology and molecular genetics are seriously challenging the assumption that human lifespans are beyond our
control.
With such discoveries in mind, noted cell biologist William R. Clark clearly and skillfully describes how senescence begins at the level of individual cells and how cellular replication may be bound up with aging of the entire organism. He explores the evolutionary origin and function of aging, the cellular connections between aging and cancer, the parallels between cellular senescence and Alzheimer's disease, and the insights gained through studying human genetic disorders-such as
Werner's syndrome-that mimic the symptoms of aging. Clark also explains how reduction in caloric intake may actually help increase lifespan, and how the destructive effects of oxidative elements in the body may be limited by the consumption of antioxidants found in fruits and vegetables. In a final
chapter, Clark considers the social and economic aspects of living longer, the implications of gene therapy on senescence, and what we might learn about aging from experiments in cloning.
This is a highly readable, provocative account of some of the most far-reaching and controversial questions we are likely to ask in the next century.
目次
- INTRODUCTION
- 1. Aging, Senescence, and Lifespan
- 2. The Nature of Cellular Senescence and Death
- 3. The Evolution of Senescence and Death
- 4. Of Embryos and Worms and Very Old Men: The Developmental Genetics of Senescence and Lifespan
- 5. Human Genetic Diseases that Mimic the Aging Process
- 6. Cycling to Senescence
- 7. Replicative Immortality: Cancer and Aging
- 8. Caloric Restriction and Maximum Lifespan
- 9. With Every Breath We Take: Oxidative Stress and Cellular Senescence
- 10. The Aging Brain
- 11. A Conditional Benefit
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