Platelet glycoprotein IIb/IIIa inhibitors in cardiovascular disease
著者
書誌事項
Platelet glycoprotein IIb/IIIa inhibitors in cardiovascular disease
（Contemporary cardiology）
Humana Press, c1999
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This book provides a definitive basis of knowledge of the use of glycoprotein IIb/IIIa inhibitors for the treatment of cardiac diseases and for the prevention of ischemic complications after percutaneous coronary intervention. The first section concentrates on the basic pathophysiology underlying the theoretical usefulness and development of this class of agents. It covers the role of thrombosis and platelet activity as well as cell surface adhesion molecules. The second section concentrates on the GP IIb/IIIa blockade following percutaneous coronary revascularization. Three agents are reviewed for this indication (abciximab Integrilin and tirofiban) with a focus on the data derived from the major Phase III trials. This section concludes with a key summary integrating the results of the major trials of GP IIb/IIIa during coronary intervention comparing and contrasting the different agents and providing practical guidelines for clinical use. The third section focuses on the emerging indication of GP IIb/IIIa blockade during the acute coronary ischemic syndromes: unstable angina and acute myocardial infarction discussing the major Phase II trials and ongoing studies in the filed.
The fourth and final section provides a vision of the future development and application of these agents for the treatment of vascular disease including the new frontier of chronic antiplatelet therapy with oral GP IIb/IIIa agents and the potential role of these agents in non-coronary (peripheral and cerebral) vascular disease.
目次
Part I. Basic Principles. Thrombosis in Acute Coronary Syndromes and Coronary Interventions Thaddeus R. Tolleson and Robert A. Harrington. Mechanisms of Platelet Adhesion Edward F. Plow. GPIIb/IIIa in Platelet Aggregation and Acute Arterial Thrombosis Debbie A. Law and David R. Phillips. GPIIb/IIIa Antagonists: Development of Abciximab and Pharmacology of Select Agents. Part III. GP IIb/IIIa Blockade During Coronary Intervention. Abciximab in Coronary Intervention: EPIC EPILOG EPISTENT Trials A. Michael Lincoff. Integrilin in Coronary Intervention: The IMPACT Trials Conor O'Shea and James E. Tcheng. Tirofiban in Coronary Intervention: The RESTORE Trial Mohamed Y. Salame Spencer B. King III and Nicolas A. Chronos. Use of Abciximab in Therapy Resistant Unstable Angina: Clinical and Angiographic Results of the CAPTURE Pilot and the CAPTURE Study Marcel J. B. M. van den Brand and Maarten L. Simoons. Overview of the GP IIb/IIIa Interventional Trials A. Michael Lincoff and Eric J. Topol. Part III. GP IIb/IIIa Blockade for Acute Ischemic Syndromes. Unstable Angina: PURSUIT PARAGON PRISM and PRISM Plus David J. Molitemo and Harvey D. White. The Use of Glycoprotein IIb/IIIa in Acute Myocardial Infarction Adam B. Greenbaum Robert A. Harrington and E. Magnus Ohman. Part IV. Practical Issues and Future Applications. Economics of Glycoprotein IIb/IIIa Inhibition Daniel B. Mark. Monitoring Platelet Aggregation Neal S. Kleiman Wojciech Mazur and Nikki Graziadei. Oral Platelet Glycoprotein IIb/IIIa Blockade Dean J. Kereiakes and Christopher P. Cannon. Cerebrovascular Aspects of Glycoprotein IIb/IIIa Inhibitors Cathy A. Sila. The Future of Glycoprotein IIb/IIIa Inhibitors Robert M. Califf and David F. Kong.
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